ArticlePlant physiology2004
Binding of sulfonylurea by AtMRP5, an Arabidopsis multidrug resistance-related protein that functions in salt tolerance.
Article in Plant physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 74 citations in OpenAlex.
- Metabolic and Photosynthesis Analysis of Compound-Material-Mediated Saline and Alkaline Stress Tolerance in Cotton Leaves.Plants (Basel, Switzerland) · 2025Article
- Sulfonylurea Receptor Pharmacology Alters the Performance of Two Central Pattern Generating Circuits in Cancer borealis.Function (Oxford, England) · 2024Article
- The maize ATP-binding cassette (ABC) transporter ZmMRPA6 confers cold and salt stress tolerance in plants.Plant cell reports · 2023Article
- Insights into Adaptive Regulation of the Leaf-Petiole System: Strategies for Survival of Water Lily Plants under Salt Stress.International journal of molecular sciences · 2023Article
- Combined transcriptomic and metabolomic analysis reveals a role for adenosine triphosphate-binding cassette transporters and cell wall remodeling in response to salt stress in strawberry.Frontiers in plant science · 2022Article
- A CCR4-associated factor 1, OsCAF1B, confers tolerance of low-temperature stress to rice seedlings.Plant molecular biology · 2021Article
- Identification and functional characterization of ABCC transporters for Cd tolerance and accumulation in Sedum alfredii Hance.Scientific reports · 2020Article
- The Central Negative Regulator of Flooding Tolerance, the PROTEOLYSIS 6 Branch of the N-degron Pathway, Adversely Modulates Salinity Tolerance inPlants (Basel, Switzerland) · 2020Article
- Salinity stress in cotton: effects, mechanism of tolerance and its management strategies.Physiology and molecular biology of plants : an international journal of functional plant biology · 2019Review
- Transcriptome response of roots to salt stress in a salinity-tolerant bread wheat cultivar.PloS one · 2019Article
- Towards Identification of the Substrates of ATP-Binding Cassette Transporters.Plant physiology · 2018Review
- Identification and Analysis of NaHCOFrontiers in plant science · 2016Article
- Identification of early salt stress responsive proteins in seedling roots of upland cotton (Gossypium hirsutum L.) employing iTRAQ-based proteomic technique.Frontiers in plant science · 2015Article
- Shoot chloride exclusion and salt tolerance in grapevine is associated with differential ion transporter expression in roots.BMC plant biology · 2014Article
- Identification and characterization of differentially expressed transcripts in the gills of freshwater prawn (Macrobrachium rosenbergii) under salt stress.TheScientificWorldJournal · 2012Article
- Plant ABC Transporters.The arabidopsis book · 2011Article
- A novel MYBS3-dependent pathway confers cold tolerance in rice.Plant physiology · 2010Article
- Effect of transporters on the secretion of phytochemicals by the roots of Arabidopsis thaliana.Planta · 2007Article
- 3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.The EMBO journal · 2005Article
- Isolation and transcription profiling of low-O2 stress-associated cDNA clones from the flooding-stress-tolerant FR13A rice genotype.Annals of botany · 2005Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, a new member of the ABC transporter superfamily of Arabidopsis, AtMRP5, was identified and characterized. In the present work, we found that AtMRP5 can bind specifically to sulfonurea when it is expressed in HEK293 cells. We also present evidence for a new role of AtMRP5 in the salt stress response of Arabidopsis. We used reverse genetics to identify an Arabidopsis mutant (atmrp5-2) in which the AtMRP5 gene was disrupted by transferred DNA insertion. In root-bending assays using Murashige and Skoog medium supplemented with 100 mm NaCl, root growth of atmrp5-2 was substantially inhibited in contrast to the almost normal growth of wild-type seedlings. This hypersensitive response of the atmrp5-2 mutant was not observed during mannitol treatment. The root growth of the wild-type plant grown in Murashige and Skoog medium supplemented with the MRP inhibitor glibenclamide and NaCl was inhibited to a very similar extent as the root growth of atmrp5-2 grown in NaCl alone. The Na(+)-dependent reduction of root growth of the wild-type plant in the presence of glibenclamide was partially restored by diazoxide, a known K+ channel opener that reverses the inhibitory effects of sulfonylureas in animal cells. Moreover, the atmrp5-2 mutant was defective in 86Rb+ uptake. When seedlings were treated with 100 mm NaCl, atmrp5-2 seedlings accumulated less K+ and more Na+ than those of the wild type. These observations suggest that AtMRP5 is a putative sulfonylurea receptor that is involved in K+ homeostasis and, thus, also participates in the NaCl stress response.
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