ArticleProceedings of the National Academy of Sciences of the United States of America2004
Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed, 160 citations in OpenAlex.
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- Genetic dissection of active forgetting in labile and consolidated memories inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The neural circuit linking mushroom body parallel circuits induces memory consolidation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Neural circuitry of social learning in Drosophila requires multiple inputs to facilitate inter-species communication.Communications biology · 2019Article
- Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace.Cell reports · 2018Article
- Drosophila species learn dialects through communal living.PLoS genetics · 2018Article
- Elongator complex is required for long-term olfactory memory formation inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Cyclic AMP-dependent plasticity underlies rapid changes in odor coding associated with reward learning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The GAL4-based Gene-Switch system has been engineered to regulate transgene expression in Drosophila in both time and space. We constructed a Gene-Switch transgene in which Gene-Switch expression is restricted spatially by a defined mushroom body enhancer. This system allows Gene-Switch to be active only in the mushroom bodies and only on administration of the pharmacological Gene-Switch ligand RU486. This line was used to drive the expression of a rutabaga cDNA in otherwise rutabaga mutant flies. Induction of the rutabaga cDNA in the mushroom bodies only during adulthood, or during adulthood along with the larval and pupal developmental stages, corrects the olfactory memory impairment found in rutabaga mutants. Induction of the cDNA only during the larval and pupal stages was inconsequential to performance in olfactory memory tasks. These data indicate that normal rutabaga function must be expressed in adulthood for normal memory and conclusively delimit the time and space expression requirements for correcting the rutabaga memory impairment. Such combined pharmacogenetic regulation of transgene expression now allows this time and space dissection to be made for other behavioral mutants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.