ArticleRNA (New York, N.Y.)2004
Analysis of a long-range interaction between conserved domains of human telomerase RNA.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Telomerase RNA is more than a DNA template.RNA biology · 2016Review
- Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Telomere les(i/s)ons from a telomerase RNA mutant.Cell cycle (Georgetown, Tex.) · 2015Review
- The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells.Cellular & molecular biology letters · 2012Article
- Telomere lengthening and other functions of telomerase.Acta naturae · 2012Article
- RNA-protein binding interface in the telomerase ribonucleoprotein.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Architecture of human telomerase RNA.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Telomerase: an RNP enzyme synthesizes DNA.Cold Spring Harbor perspectives in biology · 2011Review
- Fluorescence-based duplex-quadruplex competition test to screen for telomerase RNA quadruplex ligands.Nucleic acids research · 2011Article
- Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA.Nucleic acids research · 2010Article
- Herpesvirus telomerase RNA(vTR)-dependent lymphoma formation does not require interaction of vTR with telomerase reverse transcriptase (TERT).PLoS pathogens · 2010Article
- Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements.RNA (New York, N.Y.) · 2009Article
- Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference.Molecular and cellular biology · 2008Article
- Dyskeratosis congenita: a disorder of defective telomere maintenance?International journal of hematology · 2005Review
- Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase.RNA (New York, N.Y.) · 2005Article
- A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation.Nucleic acids research · 2005Article
- A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Telomerase dysfunction and dyskeratosis congenita.Cytotechnology · 2004Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Telomerase is a ribonucleoprotein complex responsible for maintaining telomere length of eukaryotic chromosomes. Human telomerase has two main components, the human telomerase reverse transcriptase and the human telomerase RNA (hTR). Two domains of hTR essential for telomerase activity are the template domain, comprised of an 11-nt templating and alignment sequence, and the CR4/CR5 domain. Highly conserved residues in the CR4/CR5 domain form the stem-loop P6.1, which is important for assembly and activity of mammalian telomerase. Here, we have determined that stem-loop P6.1 can participate in a long-range RNA-RNA interaction with the template region of hTR. We characterized this interaction through mobility shift assays, mutation analysis, and UV cross-linking experiments. Mutation analysis revealed that the P6.1 loop nucleotides participate in the interaction with the template. The site of interaction at the template domain was determined via UV cross-linking experiments. These data show that an RNA-RNA interaction exists between two highly conserved regions of hTR that are critical for the higher order folding of telomerase RNA. This interaction argues for the proximity of the template and the CR4/CR5 domain, and provides the basis for a revised model of hTR, partitioning the RNA into a catalytic domain and a localization domain.
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