ArticleRNA (New York, N.Y.)2004
In vitro selection of ribozymes dependent on peptides for activity.
Article in RNA (New York, N.Y.), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Peptide conjugates with polyaromatic hydrocarbons can benefit the activity of catalytic RNAs.Chemical science · 2023Article
- Possible Emergence of Sequence Specific RNA Aminoacylation via Peptide Intermediary to Initiate Darwinian Evolution and Code Through Origin of Life.Life (Basel, Switzerland) · 2018Article
- Mapping L1 ligase ribozyme conformational switch.Journal of molecular biology · 2012Article
- Arginine cofactors on the polymerase ribozyme.PloS one · 2011Article
- The scenario on the origin of translation in the RNA world: in principle of replication parsimony.Biology direct · 2010Article
- Identification of dynamical hinge points of the L1 ligase molecular switch.RNA (New York, N.Y.) · 2010Article
- Primitive templated catalysis of a peptide ligation by self-folding RNAs.Nucleic acids research · 2009Article
- Functional nucleic acid sensors.Chemical reviews · 2009Review
- Origin and evolution of the genetic code: the universal enigma.IUBMB life · 2009Review
- Simple fluorescent sensors engineered with catalytic DNA 'MgZ' based on a non-classic allosteric design.PloS one · 2007Article
- Question 6: coevolution theory of the genetic code: a proven theory.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
- On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalization.Biology direct · 2007Article
- The cosmological model of eternal inflation and the transition from chance to biological evolution in the history of life.Biology direct · 2007Article
- Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides.Journal of the American Chemical Society · 2006Article
- Direct selection of trans-acting ligase ribozymes by in vitro compartmentalization.RNA (New York, N.Y.) · 2005Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A peptide-dependent ribozyme ligase (aptazyme ligase) has been selected from a random sequence population based on the small L1 ligase. The aptazyme ligase is activated > 18,000-fold by its cognate peptide effector, the HIV-1 Rev arginine-rich motif (ARM), and specifically recognizes the Rev ARM relative to other peptides containing arginine-rich motifs. Moreover, the aptazyme ligase can preferentially recognize the Rev ARM in the context of the full-length HIV-1 Rev protein. The only cross-reactivity exhibited by the aptazyme is toward the Tat ARM. Reselection of peptide- and protein-dependent aptazymes from a partially randomized population yielded aptazymes that could readily discriminate against the Tat ARM. These results have important implications for the development of aptazymes that can be used in arrays for the detection and quantitation of multiple cellular proteins (proteome arrays).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.