ReviewExperimental biology and medicine (Maywood, N.J.)2003
Proteins of multiple classes may participate in nongenomic steroid actions.
Review in Experimental biology and medicine (Maywood, N.J.), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Endocrine disruption through membrane estrogen receptors and novel pathways leading to rapid toxicological and epigenetic effects.The Journal of steroid biochemistry and molecular biology · 2019Review
- Xenoestrogen interference with nongenomic signaling actions of physiological estrogens in endocrine cancer cells.Steroids · 2019Article
- Rapid Glucocorticoid Feedback Inhibition of ACTH Secretion Involves Ligand-Dependent Membrane Association of Glucocorticoid Receptors.Endocrinology · 2015Article
- 17β-Estradiol Upregulated Expression of α and β Subunits of Larger-Conductance Calcium-Activated K(+) Channels (BK) via Estrogen Receptor β.Journal of molecular neuroscience : MN · 2015Article
- Helix 8 of the ligand binding domain of the glucocorticoid receptor (GR) is essential for ligand binding.Molecular and cellular endocrinology · 2015Article
- 17β-estradiol downregulated the expression of TASK-1 channels in mouse neuroblastoma N2A cells.The Journal of membrane biology · 2014Article
- Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.The Journal of biological chemistry · 2014Article
- Article
- Role of female sex hormones, estradiol and progesterone, in mast cell behavior.Frontiers in immunology · 2012Article
- Endocrine disruption via estrogen receptors that participate in nongenomic signaling pathways.The Journal of steroid biochemistry and molecular biology · 2011Review
- Combinations of physiologic estrogens with xenoestrogens alter ERK phosphorylation profiles in rat pituitary cells.Environmental health perspectives · 2011Article
- Estrogens of multiple classes and their role in mental health disease mechanisms.International journal of women's health · 2010Article
- A Combined Approach Using Patch-Clamp Study and Computer Simulation Study for Understanding Long QT Syndrome and TdP in Women.Current cardiology reviews · 2008Article
- Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells.Journal of neurochemistry · 2008Article
- Progesterone binding to the alpha1-subunit of the Na/K-ATPase on the cell surface: insights from computational modeling.Steroids · 2008Article
- Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissues.Molecular and cellular endocrinology · 2007Review
- Phosphorylation of MNAR promotes estrogen activation of phosphatidylinositol 3-kinase.Molecular and cellular biology · 2007Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Responses to steroids initiated from non-nuclear receptors impinge on a wide variety of cellular responses and utilize nearly all known signal transduction webs. While the mechanisms by which steroid receptors localize in the membrane are still unclear, it is apparent that this alternative localization allows steroid receptors to participate in a wide range of complex functions influencing cell proliferation, death, and differentiation. The central debate still remains the identity of the protein class or classes that mediate membrane-initiated (nongenomic) responses. The data thus far have supported several possibilities, including: nuclear steroid receptor-like forms in non-nuclear locations; other known (nonsteroid) membrane receptors or channels with additional steroid-binding sites; enzymes; transporters; receptors for serum steroid-binding proteins; unique and previously undescribed proteins; or chimeras of typical steroid receptor domains with other unique or known protein domains. Categorizing membrane steroid receptor proteins based exclusively on the actions of antagonists and agonists, without considering cell context and protein partnering issues, may mislead us into predicting more receptor subtypes than really exist. However, the plethora of signaling and functional outcomes may indicate the participation of more than one kind of steroid-binding protein. Resolving such unanswered questions will require future investigative focus on this alternative arm of steroid action, which is likely to yield as many therapeutic opportunities as have nuclear steroid mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.