ArticleNucleic acids research2004
RNAiDB and PhenoBlast: web tools for genome-wide phenotypic mapping projects.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
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- How can functional annotations be derived from profiles of phenotypic annotations?BMC bioinformatics · 2017Article
- Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.Nature chemical biology · 2016Article
- Digital development: a database of cell lineage differentiation in C. elegans with lineage phenotypes, cell-specific gene functions and a multiscale model.Nucleic acids research · 2016Article
- Selecting causal genes from genome-wide association studies via functionally coherent subnetworks.Nature methods · 2015Article
- Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1.Scientific data · 2015Article
- Using ontologies to study cell transitions.Journal of biomedical semantics · 2013Article
- WDDD: Worm Developmental Dynamics Database.Nucleic acids research · 2013Article
- Bottlenecks caused by software gaps in miRNA and RNAi research.Pharmaceutical research · 2012Article
- A Resource of Quantitative Functional Annotation for Homo sapiens Genes.G3 (Bethesda, Md.) · 2012Article
- COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines.Nucleic acids research · 2012Article
- Article
- RNAiAtlas: a database for RNAi (siRNA) libraries and their specificity.Database : the journal of biological databases and curation · 2012Article
- PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae.Nucleic acids research · 2012Article
- Dissection of genetic pathways in C. elegans.Methods in cell biology · 2011Review
- Cortical domain correction repositions the polarity boundary to match the cytokinesis furrow in C. elegans embryos.Development (Cambridge, England) · 2010Article
- How to understand the cell by breaking it: network analysis of gene perturbation screens.PLoS computational biology · 2010Article
- Automated microscopy for high-content RNAi screening.The Journal of cell biology · 2010Review
- Evolution of early embryogenesis in rhabditid nematodes.Developmental biology · 2009Article
- Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.Nature methods · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA interference (RNAi) is being used in large-scale genomic studies as a rapid way to obtain in vivo functional information associated with specific genes. How best to archive and mine the complex data derived from these studies provides a series of challenges associated with both the methods used to elicit the RNAi response and the functional data gathered. RNAiDB (RNAi Database; http://www. rnai.org) has been created for the archival, distribution and analysis of phenotypic data from large-scale RNAi analyses in Caenorhabditis elegans. The database contains a compendium of publicly available data and provides information on experimental methods and phenotypic results, including raw data in the form of images and streaming time-lapse movies. Phenotypic summaries together with graphical displays of RNAi to gene mappings allow quick intuitive comparison of results from different RNAi assays and visualization of the gene product(s) potentially inhibited by each RNAi experiment based on multiple sequence analysis methods. RNAiDB can be searched using combinatorial queries and using the novel tool PhenoBlast, which ranks genes according to their overall phenotypic similarity. RNAiDB could serve as a model database for distributing and navigating in vivo functional information from large-scale systematic phenotypic analyses in different organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.