ArticleDevelopment (Cambridge, England)2004
Both cyclin B levels and DNA-replication checkpoint control the early embryonic mitoses in Drosophila.
Article in Development (Cambridge, England), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Adaptive evolution of Topoisomerase II triggers reproductive isolation in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Nuclear speed and cycle length co-vary with local density during syncytial blastoderm formation in a cricket.Nature communications · 2022Article
- Transcription and splicing dynamics during earlyRNA (New York, N.Y.) · 2022Article
- Histone concentration regulates the cell cycle and transcription in early development.Development (Cambridge, England) · 2019Article
- Metabolic Regulation of Developmental Cell Cycles and Zygotic Transcription.Current biology : CB · 2019Article
- A homeostatic clock sets daughter centriole size in flies.The Journal of cell biology · 2018Article
- Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo.Development (Cambridge, England) · 2016Article
- Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.Trends in genetics : TIG · 2016Review
- Zygotic genome activation triggers the DNA replication checkpoint at the midblastula transition.Cell · 2015Article
- Investigating spermatogenesis in Drosophila melanogaster.Methods (San Diego, Calif.) · 2014Review
- An essential role for zygotic expression in the pre-cellular Drosophila embryo.PLoS genetics · 2013Article
- Noncanonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seq.PLoS biology · 2011Article
- Article
- DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos.The Journal of cell biology · 2009Article
- Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition.Development (Cambridge, England) · 2009Article
- Influence of cyclin type and dose on mitotic entry and progression in the early Drosophila embryo.The Journal of cell biology · 2009Article
- no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila.Development (Cambridge, England) · 2009Article
- Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation.The Journal of cell biology · 2008Article
- Control of cell cycle timing during C. elegans embryogenesis.Developmental biology · 2008Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The earliest embryonic mitoses in Drosophila, as in other animals except mammals, are viewed as synchronous and of equal duration. However, we observed that total cell-cycle length steadily increases after cycle 7, solely owing to the extension of interphase. Between cycle 7 and cycle 10, this extension is DNA-replication checkpoint independent, but correlates with the onset of Cyclin B oscillation. In addition, nuclei in the middle of embryos have longer metaphase and shorter anaphase than nuclei at the two polar regions. Interestingly, sister chromatids move faster in anaphase in the middle than the posterior region. These regional differences correlate with local differences in Cyclin B concentration. After cycle 10, interphase and total cycle duration of nuclei in the middle of the embryo are longer than at the poles. Because interphase also extends in checkpoint mutant (grapes) embryo after cycle 10, although less dramatic than wild-type embryos, interphase extension after cycle 10 is probably controlled by both Cyclin B limitation and the DNA-replication checkpoint.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.