ArticleJournal of clinical epidemiology2003
A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection.
Article in Journal of clinical epidemiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Burden of respiratory syncytial virus infection in older and high-risk adults: a systematic review and meta-analysis of the evidence from developed countries.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2020Pooled it
- Trial
- A decade of endemic human coronaviruses: epidemiological patterns and clinical significance in an adult cohort at a tertiary care hospital in Germany.BMC infectious diseases · 2026Article
- Global Epidemiology and Seasonality of Human Seasonal Coronaviruses: A Systematic Review.Open forum infectious diseases · 2024Article
- Bacterial and viral etiology of acute respiratory infection among the Forcibly Displaced Myanmar Nationals (FDMNs) in fragile settings in Cox's Bazar- a prospective case-control study.PLoS neglected tropical diseases · 2023Article
- Solid waste motor tricycle operators in Kumasi, Ghana, harbour respiratory pathogens; a public health threat.PloS one · 2023Article
- Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic.Cell host & microbe · 2022Article
- Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period.bioRxiv : the preprint server for biology · 2022Article
- Endemic and Emerging Coronavirus Pulmonary Infections.The American journal of the medical sciences · 2020Article
- Advances in the relationship between coronavirus infection and cardiovascular diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Review
- Coronavirus disease 2019 (COVID-19): research progress and clinical practice.Global health & medicine · 2020Review
- SARS-CoV-2 Genomes From Oklahoma, United States.Frontiers in genetics · 2020Article
- PCR Detection of Respiratory Pathogens in Asymptomatic and Symptomatic Adults.Journal of clinical microbiology · 2019Article
- Epidemiology and Clinical Features of Human Coronaviruses in the Pediatric Population.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Hosts and Sources of Endemic Human Coronaviruses.Advances in virus research · 2018Review
- Respiratory Syncytial Virus and Other Noninfluenza Respiratory Viruses in Older Adults.Infectious disease clinics of North America · 2017Review
- Viral respiratory infections in a nursing home: a six-month prospective study.BMC infectious diseases · 2016Article
- Predictors of influenza among older adults in the emergency department.BMC infectious diseases · 2016Article
- Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia.The Journal of infectious diseases · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesCommunity-based elderly studies concerning microbiology of acute respiratory infections are scarce. Data on subclinical infections are even totally absent, although asymptomatic persons might act as a source of respiratory infections.
methodsIn a 1-year community-based study, we prospectively investigated the possible virologic cause of acute respiratory infections in 107 symptomatic case episodes and 91 symptom-free control periods. Participants, persons >/=60 years, reported daily the presence of respiratory symptoms in a diary. Virologic assessment was performed by polymerase chain reaction (PCR) and serology.
resultsIn 58% of the case episodes a pathogen was demonstrated, the most common being rhinoviruses (32%), coronaviruses (17%), and influenzaviruses (7%). The odds ratio for demonstrating a virus in cases with symptoms vs. controls without symptoms was 30.0 (95% confidence interval 10.2-87.6). In 4% of the symptom-free control periods a virus was detected.
conclusionsThis study supports the importance of rhinovirus infections in community-dwelling elderly persons, whereas asymptomatic elderly persons can also harbor pathogens as detected by PCR, and thus might be a source of infection for their environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.