ReviewCurrent allergy and asthma reports2004
Analysis of leukocyte extravasation across the blood-brain barrier: conceptual and technical aspects.
Review in Current allergy and asthma reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Profiling Peripheral Blood with an Optimized, Multiplexed, Single-cell Multiome Approach Supports an Insulin-driven Asthma Subtype.bioRxiv : the preprint server for biology · 2026Article
- Controversies and insights into cytokine regulation of neurogenesis and behavior in adult rodents.Frontiers in immunology · 2025Review
- Immune responses to injury and their links to eye disease.Translational research : the journal of laboratory and clinical medicine · 2021Review
- The Role of Neuroinflammation in Glaucoma: An Update on Molecular Mechanisms and New Therapeutic Options.Frontiers in neurology · 2020Review
- Adaptive Immunity: New Aspects of Pathogenesis Underlying Neurodegeneration in Glaucoma and Optic Neuropathy.Frontiers in immunology · 2020Review
- Neuroinflammation and microglia in glaucoma: time for a paradigm shift.Journal of neuroscience research · 2019Review
- Ethanol and Cytokines in the Central Nervous System.Handbook of experimental pharmacology · 2018Review
- The complex role of neuroinflammation in glaucoma.Cold Spring Harbor perspectives in medicine · 2014Review
- Contributions of the immune system to the pathophysiology of traumatic brain injury - evidence by intravital microscopy.Frontiers in cellular neuroscience · 2014Review
- Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.BMC genomics · 2012Article
- Inherited variation in immune genes and pathways and glioblastoma risk.Carcinogenesis · 2010Article
- Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Article
- Mechanisms of leukocyte migration across the blood-retina barrier.Seminars in immunopathology · 2008Review
- Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The central nervous system (CNS) has long been described as an immunologically privileged organ. However, evidence is accumulating that the CNS is more adequately described as immune competent, albeit atypical. Leukocyte trafficking into the CNS in response to inflammation, as in peripheral organs, occurs in several distinct steps. As with all leukocyte trafficking, the overall process is governed in part by chemokines. The CNS has unique anatomic and physiologic attributes, including the blood-brain barrier. These characteristic features of the CNS interact with a distinct array of chemokines, expressed both constitutively and in response to inflammation. In this review, we consider the potential sites of chemokine action in guiding leukocyte migration. The process of extravasation can usefully be regarded as comprising individual steps. This review is focused on the need to consider these stages separately, and the elucidation of mechanisms at each stage is outlined.
Indexed as
Identifiers
14680625What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.