ArticleArthritis research & therapy2003
Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats.
Article in Arthritis research & therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis.Journal of immunology research · 2018Article
- Adjuvants- and vaccines-induced autoimmunity: animal models.Immunologic research · 2017Article
- c-kit plays a critical role in induction of intravenous tolerance in experimental autoimmune encephalomyelitis.Immunologic research · 2015Article
- Comparative antigen-induced gene expression profiles unveil novel aspects of susceptibility/resistance to adjuvant arthritis in rats.Molecular immunology · 2013Article
- Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models.Clinical & developmental immunology · 2012Review
- The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge.Arthritis research & therapy · 2011Article
- Microarray-based approach identifies differentially expressed microRNAs in porcine sexually immature and mature testes.PloS one · 2010Article
- Gene expression profiling as a tool for positional cloning of genes-shortcut or the longest way round.Current genomics · 2008Article
- Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation.Arthritis research & therapy · 2005Article
- Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis.Arthritis research & therapy · 2005Article
- Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies.Arthritis research & therapy · 2004Review
- 4th meeting of the EU research network EUROME: from the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004.Arthritis research & therapy · 2004Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. Inguinal lymph nodes of naïve animals and animals 8 days after pristane injection were analyzed for differential gene expression. mRNA expression was investigated by microarray and real-time PCR, and protein expression was analyzed by flow cytometry or ELISA. Twelve genes were significantly differentially expressed when analyzed by at least two independent methods, and an additional five genes showed a strong a tendency toward differential expression. In naïve DA rats IgE, the bone marrow stromal cell antigen 1 (Bst1) and the MHC class II beta-chain (MhcII) were expressed at a higher level, and the immunoglobulin kappa chain (Igkappa) was expressed at a lower level. In pristane-treated DA rats the MHC class II beta-chain, gelatinase B (Mmp9) and the protein tyrosine phosphatase CL100 (Ptpn16) were expressed at a higher level, whereas immunoglobulins, the CD28 molecule (Cd28), the mast cell specific protease 1 (Mcpt1), the carboxylesterase precursor (Ces2), K-cadherin (Cdh6), cyclin G1 (Ccng1), DNA polymerase IV (Primase) and the tumour associated glycoprotein E4 (Tage) were expressed at a lower level. Finally, the differentially expressed mRNA was confirmed with protein expression for some of the genes. In conclusion, the results show that animal models are well suited for reproducible microarray analysis of candidate genes for arthritis. All genes have functions that are potentially important for arthritis, and nine of the genes are located within genomic regions previously associated with autoimmune disease.
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