ArticleThe Biochemical journal2004
Expression of YAP4 in Saccharomyces cerevisiae under osmotic stress.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Yeast AP-1 like transcription factors (Yap) and stress response: a current overview.Microbial cell (Graz, Austria) · 2019Review
- A Network of Paralogous Stress Response Transcription Factors in the Human Pathogen Candida glabrata.Frontiers in microbiology · 2016Article
- The yeast BDF1 regulates endocytosis via LSP1 under salt stress.Current microbiology · 2015Article
- Statistical analysis reveals co-expression patterns of many pairs of genes in yeast are jointly regulated by interacting loci.PLoS genetics · 2013Article
- Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance.Physiological genomics · 2011Article
- An integrative multi-network and multi-classifier approach to predict genetic interactions.PLoS computational biology · 2010Article
- Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae.Biochemistry · 2009Article
- Sugar metabolism, redox balance and oxidative stress response in the respiratory yeast Kluyveromyces lactis.Microbial cell factories · 2009Article
- Dynamic and complex transcription factor binding during an inducible response in yeast.Genes & development · 2009Article
- Quinone reductase acts as a redox switch of the 20S yeast proteasome.EMBO reports · 2009Article
- Structure and function of a transcriptional network activated by the MAPK Hog1.Nature genetics · 2008Article
- A systematic approach to detecting transcription factors in response to environmental stresses.BMC bioinformatics · 2007Article
- Refinement and expansion of signaling pathways: the osmotic response network in yeast.Genome research · 2007Article
- Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan.Eukaryotic cell · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
YAP4, a member of the yeast activator protein ( YAP ) gene family, is induced in response to osmotic shock in the yeast Saccharomyces cerevisiae. The null mutant displays mild and moderate growth sensitivity at 0.4 M and 0.8 M NaCl respectively, a fact that led us to analyse YAP4 mRNA levels in the hog1 (high osmolarity glycerol) mutant. The data obtained show a complete abolition of YAP4 gene expression in this mutant, placing YAP4 under the HOG response pathway. YAP4 overexpression not only suppresses the osmosensitivity phenotype of the yap4 mutant but also relieves that of the hog1 mutant. Induction, under the conditions tested so far, requires the presence of the transcription factor Msn2p, but not of Msn4p, as YAP4 mRNA levels are depleted by at least 75% in the msn2 mutant. This result was further substantiated by the fact that full YAP4 induction requires the two more proximal stress response elements. Furthermore we find that GCY1, encoding a putative glycerol dehydrogenase, GPP2, encoding a NAD-dependent glycerol-3-phosphate phosphatase, and DCS2, a homologue to a decapping enzyme, have decreased mRNA levels in the yap4 -deleted strain. Our data point to a possible, as yet not entirely understood, role of the YAP4 in osmotic stress response.
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