ArticleThe Biochemical journal2004
Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- Exploring the proton transport mechanism of the mitochondrial ADP/ATP carrier: FA-cycling hypothesis and beyond.Protein science : a publication of the Protein Society · 2025Review
- Understanding coenzyme Q.Physiological reviews · 2024Review
- Coenzyme Q biochemistry and biosynthesis.Trends in biochemical sciences · 2023Review
- CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression.Antioxidants (Basel, Switzerland) · 2022Article
- Metabolic Targets of Coenzyme Q10 in Mitochondria.Antioxidants (Basel, Switzerland) · 2021Review
- The Paradox of Coenzyme QNutrients · 2019Review
- Important Trends in UCP3 Investigation.Frontiers in physiology · 2019Review
- Cell-free production and characterisation of human uncoupling protein 1-3.Biochemistry and biophysics reports · 2017Article
- The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism.Biochimie · 2017Review
- Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Test systems to study the structure and function of uncoupling protein 1: a critical overview.Frontiers in endocrinology · 2011Article
- TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone.Toxicology and applied pharmacology · 2006Article
- Accumulation of lipophilic dications by mitochondria and cells.The Biochemical journal · 2006Article
- Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria.The Biochemical journal · 2006Article
- UPR-independent dithiothreitol stress-induced genes in Aspergillus niger.Molecular genetics and genomics : MGG · 2005Article
- A possible site of superoxide generation in the complex I segment of rat heart mitochondria.Journal of bioenergetics and biomembranes · 2005Article
- Redox state of endogenous coenzyme q modulates the inhibition of linoleic acid-induced uncoupling by guanosine triphosphate in isolated skeletal muscle mitochondria.Journal of bioenergetics and biomembranes · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Q (coenzyme Q or ubiquinone) is reported to be a cofactor obligatory for proton transport by UCPs (uncoupling proteins) in liposomes [Echtay, Winkler and Klingenberg (2000) Nature (London) 408, 609-613] and for increasing the binding of the activator retinoic acid to UCP1 [Tomás, Ledesma and Rial (2002) FEBS Lett. 526, 63-65]. In the present study, yeast ( Saccharomyces cerevisiae ) mutant strains lacking Q and expressing UCP1 were used to determine whether Q was required for UCP function in mitochondria. Wild-type yeast strain and two mutant strains (CENDeltaCOQ3 and CENDeltaCOQ2), both not capable of synthesizing Q, were transformed with the mouse UCP1 gene. UCP1 activity was measured as fatty acid-dependent, GDP-sensitive proton conductance in mitochondria isolated from the cells. The activity of UCP1 was similar in both Q-containing and -deficient yeast mitochondria. We conclude that Q is neither an obligatory cofactor nor an activator of proton transport by UCP1 when it is expressed in yeast mitochondria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.