ReviewThe Journal of clinical investigation2003
It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.
Review in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- An Unusual Intraosseous Swelling of the Jaw: Two Rare Case Reports.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model.Frontiers in oncology · 2023Article
- AfterNeuro-oncology advances · 2020Review
- Cutaneous neurofibromas in the genomics era: current understanding and open questions.British journal of cancer · 2018Review
- The plexiform neurofibroma microenvironment.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.Cancer research · 2012Article
- Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.Sarcoma · 2012Article
- Occipital peripheral nerve stimulation in the management of chronic intractable occipital neuralgia in a patient with neurofibromatosis type 1: a case report.Journal of medical case reports · 2011Article
- Ulcerative colitis and neurofibromatosis type 1 with bilateral psoas muscle neurofibromas: a case report.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2009Article
- Neuro-oncology of Neurofibromatosis Type 1.Current treatment options in neurology · 2009Article
- Solitary fibrous tumor of the oral cavity: clinicopathologic and immunohistochemical study of 21 cases.Head and neck pathology · 2009Article
- Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.Blood · 2008Article
- Midline cutaneous lumbosacral lesions: not always a sign of occult spinal dysraphism.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2006Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could influence the multicellular microenvironment of neurofibromas to inhibit the development and/or progression of these tumors in human NF1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.