Evidence map›Paper›PMID 14678335›Full record

ReviewBritish journal of clinical pharmacology2004

Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications.

A A Mangoni, S H D Jackson

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04663360 (Medication Monitoring in General Practice), which is not on this map. Cited by 817 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
817citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04663360 nacompletednot on this mapstarted 2020, after this paper: background citation

Medication Monitoring in General Practice: Clinical Impact of Implementing a Nurse-led Adverse Drug Reaction (ADRe) Profile in Older Adults With 5 or More Prescribed Medicines

TypeinterventionalSponsorSwansea UniversityRan2020 to 2020Enrolled19ConditionsPolypharmacyArmsAdverse Drug Reaction (ADRe) Profile
3 · Its place in the literature

Who cites it

817 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Predictors of clinical response to biologics in psoriasis: A systematic review and meta-analysis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
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757 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

A A MangoniDepartment of Health Care of the Elderly, Guy's, King's, and St Thomas' School of Medicine, King's College London, London. arduino.mangoni@kcl.ac.uk
S H D Jackson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancing age is characterized by impairment in the function of the many regulatory processes that provide functional integration between cells and organs. Therefore, there may be a failure to maintain homeostasis under conditions of physiological stress. The reduced homeostatic ability affects different regulatory systems in different subjects, thus explaining at least partly the increased interindividual variability occurring as people get older. Important pharmacokinetic and pharmacodynamic changes occur with advancing age. Pharmacokinetic changes include a reduction in renal and hepatic clearance and an increase in volume of distribution of lipid soluble drugs (hence prolongation of elimination half-life) whereas pharmacodynamic changes involve altered (usually increased) sensitivity to several classes of drugs such as anticoagulants, cardiovascular and psychotropic drugs. This review focuses on the main age-related physiological changes affecting different organ systems and their implications for pharmacokinetics and pharmacodynamics of drugs.

Indexed as

PharmacokineticsPharmacologyAgingBiological AvailabilityDigestive SystemHeartHumansKidneyMetabolic Clearance RateNeurosecretory SystemsProtein Binding

Identifiers

PMID14678335
PMCPMC1884408

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.