ArticleImmunology2004
Nerve fibres are required to evoke a contact sensitivity response in mice.
Article in Immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Langerhans cells: Central players in the pathophysiology of atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- Skin Inflammation with a Focus on Wound Healing.Advances in wound care · 2023Review
- Regional differences in cell-mediated immunity in people with diabetic peripheral neuropathy.Diabetic medicine : a journal of the British Diabetic Association · 2020Article
- Toward the Existence of a Sympathetic Neuroplasticity Adaptive Mechanism Influencing the Immune Response. A Hypothetical View-Part II.Frontiers in endocrinology · 2019Article
- Skin neurogenic inflammation.Seminars in immunopathology · 2018Review
- Sensory TRP channels contribute differentially to skin inflammation and persistent itch.Nature communications · 2017Article
- TRPA1 mediated aggravation of allergic contact dermatitis induced by DINP and regulated by NF-κB activation.Scientific reports · 2017Article
- Sense and Immunity: Context-Dependent Neuro-Immune Interplay.Frontiers in immunology · 2017Review
- Central neural activation following contact sensitivity peripheral immune challenge: evidence of brain-immune regulation through C fibres.Immunology · 2015Article
- The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease.Trends in immunology · 2015Review
- Crosstalk between the nociceptive and immune systems in host defence and disease.Nature reviews. Neuroscience · 2015Review
- Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis.Frontiers in neuroscience · 2014Review
- TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Antimicrobial anxiety: the impact of stress on antimicrobial immunity.Journal of leukocyte biology · 2010Review
- Review
- Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice.The American journal of pathology · 2006Article
- Without nerves, immunology remains incomplete -in vivo veritas.Immunology · 2005Review
- Close encounters of the monoamine kind: immune cells betray their nervous disposition.Immunology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Previous work has indicated that the dermis and epidermis of skin contains abundant nerve fibres closely associated with Langerhans' cells. We have investigated whether these nerve endings are necessary for inducing and evoking a contact sensitivity (CS) response. Topical application of a general or a peptide (calcitonin gene-related peptide and substance P)-specific neurotoxin was employed to destroy the nerve fibres at skin sites subsequently used to induce or evoke the CS response. Elimination of nerve fibres abolished both induction and effector stages of the specific CS response. Denervation did not destroy the local Langerhans' cells, which were observed in increased numbers, or prevent them from migrating to lymph nodes. The local CS response was also abolished by systemic deletion of capsaicin-sensitive nerve fibres, suggesting that the loss of response was not non-specific but associated with the loss of specific nerve fibres. The results indicate that peptidergic nerve fibres are required to elicit a CS response and may be vital to the normal function of the immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.