ArticleJournal of muscle research and cell motility2003
Lower active force generation and improved fatigue resistance in skeletal muscle from desmin deficient mice.
Article in Journal of muscle research and cell motility, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Biomechanical Properties of the Sarcolemma and Costameres of Skeletal Muscle Lacking Desmin.Frontiers in physiology · 2021Article
- Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using theInternational journal of molecular sciences · 2020Article
- Deficiency of the intermediate filament synemin reduces bone mass in vivo.American journal of physiology. Cell physiology · 2016Article
- Knockdown of desmin in zebrafish larvae affects interfilament spacing and mechanical properties of skeletal muscle.The Journal of general physiology · 2013Article
- Viral-mediated expression of desmin mutants to create mouse models of myofibrillar myopathy.Skeletal muscle · 2013Article
- Desminopathies: pathology and mechanisms.Acta neuropathologica · 2013Review
- Evolving concepts on the age-related changes in "muscle quality".Journal of cachexia, sarcopenia and muscle · 2012Article
- Increased desmin expression in hindlimb muscles of aging rats.Journal of cachexia, sarcopenia and muscle · 2011Article
- Theoretical predictions of the effects of force transmission by desmin on intersarcomere dynamics.Biophysical journal · 2010Article
- Effects of electrical stimulation in C2C12 muscle constructs.Journal of tissue engineering and regenerative medicine · 2008Article
- Desmin stimulates differentiation of cardiomyocytes and up-regulation of brachyury and nkx2.5.Differentiation; research in biological diversity · 2007Article
- Differentiation of cardiomyocytes requires functional serine residues within the amino-terminal domain of desmin.Differentiation; research in biological diversity · 2007Article
- Phospholipase C and cAMP-dependent positive inotropic effects of ATP in mouse cardiomyocytes via P2Y11-like receptors.Journal of molecular and cellular cardiology · 2005Article
- Desmin filaments influence myofilament spacing and lateral compliance of slow skeletal muscle fibers.Biophysical journal · 2005Article
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Authors and funding
4 authors.
Funding
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Abstract
The mechanical effects of the intermediate filament protein desmin was examined in desmin deficient mice (Des-/-) and their wild type control (Des+/+). Active force generation was determined in intact soleus muscles and in skinned single fibres from soleus and psoas. A decreased force generation of skinned muscle fibres from Des-/- mice and a tendency towards decreased active force in intact soleus muscle were detected. Concentrations of the contractile protein actin and myosin were not altered in Des-/- muscles. Ca(2+)-sensitivity of skinned single fibres in Des-/- muscles was unchanged compared to Des+/+. Using a protocol with repeated short tetani an increased fatigue resistance was found in the intact soleus muscles from Des-/- mice. In conclusion, desmin intermediate filaments are required for optimal generation or transmission of active force in skeletal muscle. Although other studies have shown that the desmin intermediate filaments appear to influence Ca(2+)-handling, the Ca(2+)-sensitivity of the contractile filaments is not altered in skeletal muscle of Des-/- mice. Previous studies have reported a switch towards slower myosin isoforms in slow skeletal muscle of Des-/- mice. The increased fatigue resistance show that this change is reflected in the physiological function of the muscle.
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