ArticleOncogene2004
Transcriptional regulation by the estrogen receptor of antioxidative stress enzymes and its functional implications.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Identification of candidate polymorphisms on stress oxidative and DNA damage repair genes related with clinical outcome in breast cancer patients.International journal of molecular sciences · 2012Trial
- Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia.Frontiers in endocrinology · 2025Review
- N-acetyl Cysteine Overdose Induced Acute Toxicity and Hepatic Microvesicular Steatosis by Disrupting GSH and Interfering Lipid Metabolisms in Normal Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Reactive Oxygen Species in the Reproductive System: Sources and Physiological Roles.Advances in experimental medicine and biology · 2022Article
- Detection and functional characterization of sigma class GST in Phlebotomus argentipes and its role in stress tolerance and DDT resistance.Scientific reports · 2019Article
- The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis.Redox biology · 2016Article
- Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection.European journal of pharmacology · 2014Article
- Cytoprotection "gone astray": Nrf2 and its role in cancer.OncoTargets and therapy · 2014Review
- Roles of reactive oxygen species in the spermatogenesis regulation.Frontiers in endocrinology · 2014Review
- The prognostic and predictive power of redox protein expression for anthracycline-based chemotherapy response in locally advanced breast cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2012Article
- Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.Nucleic acids research · 2012Article
- Silencing of GSTP1, a prostate cancer prognostic gene, by the estrogen receptor-β and endothelial nitric oxide synthase complex.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Article
- The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk.The Journal of steroid biochemistry and molecular biology · 2011Article
- Regulation of estrogen receptor beta activity and implications in health and disease.Cellular and molecular life sciences : CMLS · 2009Review
- Follicle-stimulating hormone and estradiol interact to stimulate glutathione synthesis in rat ovarian follicles and granulosa cells.Biology of reproduction · 2009Article
- Influence of glutathione S-transferase polymorphisms on cognitive functioning effects induced by p,p'-DDT among preschoolers.Environmental health perspectives · 2008Article
- Article
- Protective roles of quinone reductase and tamoxifen against estrogen-induced mammary tumorigenesis.Oncogene · 2007Article
- Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study.Respiratory research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We previously reported that antiestrogen-liganded estrogen receptor beta (ERbeta) transcriptionally activates the major detoxifying enzyme quinone reductase (QR) (NAD(P)H:quinone oxidoreductase). Our studies also indicate that upregulation of QR, either by overexpression or induction by tamoxifen, can protect breast cells against oxidative DNA damage caused by estrogen metabolites. We now report on the upregulation of glutathione S-transferases Pi (GST-Pi) and gamma-glutamylcysteine synthetase heavy subunit (GCSh) expression by antiestrogens. Studies indicate the regulation of GST-Pi and GCSh transcriptional activity by ER. While ER regulation is mediated by an electrophile response element (EpRE), we identified mechanistic differences in the involvement of other transcription factors. Regardless of these differences, ER beta-mediated regulation of GST-Pi and GCSh point towards an important role for ER beta in cellular protection against oxidative stress. A protective role is supported by our observation of inhibition of estrogen-induced DNA damage upon upregulation of GST-Pi and GCSh expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.