ArticleThe Journal of cell biology2003
Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Endothelial signaling by neutrophil-released oncostatin M enhances P-selectin-dependent inflammation and thrombosis.Blood advances · 2019Article
- Effects of shear on P-selectin deposition in microfluidic channels.Biomicrofluidics · 2016Article
- Pathogenesis of diabetic cerebral vascular disease complication.World journal of diabetes · 2015Review
- Diabetes alters the expression of partial vasoactivators in cerebral vascular disease susceptible regions of the diabetic rat.Diabetology & metabolic syndrome · 2013Article
- Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Article
- The essential role of clathrin-mediated endocytosis in the infectious entry of human enterovirus 71.The Journal of biological chemistry · 2011Article
- Biomechanics of leukocyte rolling.Biorheology · 2011Review
- Differential regulation of human and murine P-selectin expression and function in vivo.The Journal of experimental medicine · 2010Article
- Upregulation of coronary endothelial P-selectin in a monkey heart ischemia reperfusion model.Journal of molecular histology · 2010Article
- Rolling cell adhesion.Annual review of cell and developmental biology · 2010Review
- Platelets enhance endothelial adhesiveness in high tidal volume ventilation.American journal of respiratory cell and molecular biology · 2008Article
- Article
- Bacterial cytotoxins: targeting eukaryotic switches.Nature reviews. Microbiology · 2005Review
- Rho GTPases and leucocyte-induced endothelial remodelling.The Biochemical journal · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Flowing leukocytes roll on P-selectin that is mobilized from secretory granules to the surfaces of endothelial cells after stimulation with histamine or thrombin. Before it is internalized, P-selectin clusters in clathrin-coated pits, which enhances its ability to support leukocyte rolling. We found that thrombin and histamine induced comparable exocytosis of P-selectin on endothelial cells. However, compared with histamine, thrombin decreased the recruitment of P-selectin into clathrin-coated pits, slowed the internalization of P-selectin, and reduced the number and stability of neutrophils rolling on P-selectin. Significantly more RhoA was activated in thrombin- than in histamine-stimulated endothelial cells. Inhibitors of RhoA or its effector, Rho kinase, reversed thrombin's ability to inhibit the internalization and adhesive function of P-selectin in endothelial cells. Experiments with transfected cells confirmed that the inhibitory actions of thrombin and Rho kinase on P-selectin required its cytoplasmic domain. Thus, a signaling event affects both the function and clearance of a protein that enters the constitutive clathrin-mediated endocytic pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.