ArticleMolecular and cellular biochemistry2003
An aging-related cell surface NADH oxidase (arNOX) generates superoxide and is inhibited by coenzyme Q.
Article in Molecular and cellular biochemistry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 47 citations in OpenAlex.
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- Effect of Coenzyme Q10 and transcutaneous electrical acupoint stimulation in assisted reproductive technology: a retrospective controlled study.Reproductive biology and endocrinology : RB&E · 2022Article
- Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review.Reproductive biology and endocrinology : RB&E · 2022Review
- Recent Advancements in In Vitro Fertilisation.Cureus · 2022Review
- Recent advances inF1000Research · 2017Review
- Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.Aging cell · 2015Article
- Ox-PAPC activation of PMET system increases expression of heme oxygenase-1 in human aortic endothelial cell.Journal of lipid research · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
This report describes a novel ECTO-NOX protein with an oscillating activity having a period length of ca. 26 min encountered with buffy coat fractions and sera of aged individuals (70-100 years) that generates superoxide as measured by the reduction of ferricytochrome c. The oscillating, age-related reduction of ferricytochrome c is sensitive to superoxide dismutase, is inhibited by coenzyme Q and is reduced or absent from sera of younger individuals (20-40 years). An oscillating activity with a regular period length is a defining characteristic of ECTO-NOX proteins (a group of cell surface oxidases with enzymatic activities that oscillate). The period length of ca. 26 min is longer than the period length of 24 min for the usual constitutive (CNOX) ECTO-NOX proteins of the cell surface and sera which neither generate superoxide nor reduce ferricytochrome c. The aging-related ECTO-NOX protein (arNOX) provides a mechanism to transmit cell surface oxidative changes to surrounding cells and circulating lipoproteins potentially important to atherogenesis. Additionally, the findings provide a rational basis for the use of dietary coenzyme Q to retard aging-related arterial lesions.
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