ArticleDevelopment genes and evolution2004
Sex determination in Drosophila melanogaster and Musca domestica converges at the level of the terminal regulator doublesex.
Article in Development genes and evolution, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed.
- A shared gene but distinct dynamics regulate mimicry polymorphisms in closely related butterfly species.Proceedings. Biological sciences · 2025Article
- Doublesex and GATAβ4 synergistically regulate the sex-dimorphic expression of storage protein 1 in Bombyx mori.PLoS genetics · 2025Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- Establishing a dominant early larval sex-selection strain in the Asian malaria vector Anopheles stephensi.Infectious diseases of poverty · 2024Article
- Female Sex Determination Factors inInsects · 2023Article
- CRISPR/Cas9-Mediated Mutagenesis of Sex-SpecificCells · 2022Article
- CRISPR/Cas9 mediated sex-ratio distortion by sex specific gene editing inSaudi journal of biological sciences · 2022Article
- Genetic, morphometric, and molecular analyses of interspecies differences in head shape and hybrid developmental defects in the wasp genus Nasonia.G3 (Bethesda, Md.) · 2021Article
- Conditional knockdown of transformer in sheep blow fly suggests a role in repression of dosage compensation and potential for population suppression.PLoS genetics · 2021Article
- Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs.Communications biology · 2020Article
- Minimal Effects of Proto-Genetics · 2019Article
- Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera).BMC genomics · 2019Article
- Precise staging of beetle horn formation in Trypoxylus dichotomus reveals the pleiotropic roles of doublesex depending on the spatiotemporal developmental contexts.PLoS genetics · 2019Article
- A genetic switch for worker nutrition-mediated traits in honeybees.PLoS biology · 2019Article
- Article
- CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus.Scientific reports · 2017Article
- The C-terminus of DSX(F5) protein acts as a novel regulatory domain in Bombyx mori.Transgenic research · 2016Article
- The autoregulatory loop: A common mechanism of regulation of key sex determining genes in insects.Journal of biosciences · 2016Review
- Identification and Characterization of Sex-Biased MicroRNAs in Bactrocera dorsalis (Hendel).PloS one · 2016Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
2 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Sex-determining cascades are supposed to have evolved in a retrograde manner from bottom to top. Wilkins' 1995 hypothesis finds support from our comparative studies in Drosophila melanogaster and Musca domestica, two dipteran species that separated some 120 million years ago. The sex-determining cascades in these flies differ at the level of the primary sex-determining signal and their targets, Sxl in Drosophila and F in Musca. Here we present evidence that they converge at the level of the terminal regulator, doublesex ( dsx), which conveys the selected sexual fate to the differentiation genes. The dsx homologue in Musca, Md-dsx, encodes male-specific (MdDSX(M)) and female-specific (MdDSX(F)) protein variants which correspond in structure to those in Drosophila. Sex-specific regulation of Md-dsx is controlled by the switch gene F via a splicing mechanism that is similar but in some relevant aspects different from that in Drosophila. MdDSX(F) expression can activate the vitellogenin genes in Drosophila and Musca males, and MdDSX(M) expression in Drosophila females can cause male-like pigmentation of posterior tergites, suggesting that these Musca dsx variants are conserved not only in structure but also in function. Furthermore, downregulation of Md-dsx activity in Musca by injecting dsRNA into embryos leads to intersexual differentiation of the gonads. These results strongly support a role of Md-dsx as the final regulatory gene in the sex-determining hierarchy of the housefly.
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