ArticleHuman genetics2004
Localized aggressive periodontitis is linked to human chromosome 1q25.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 55 citations in OpenAlex.
- Epigenetic regulation of inflammation in localized aggressive periodontitis.Clinical epigenetics · 2017Trial
- Association of P2RX7 functional variants with localized aggressive periodontitis.Journal of periodontal research · 2020Article
- Associations ofJDR clinical and translational research · 2019Article
- Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque.Journal of clinical periodontology · 2016Article
- Review
- Epigenetic biomarkers: a step forward for understanding periodontitis.Journal of periodontal & implant science · 2013Article
- Ehlers-Danlos syndrome type VIII is clinically heterogeneous disorder associated primarily with periodontal disease, and variable connective tissue features.European journal of human genetics : EJHG · 2013Article
- FAM5C contributes to aggressive periodontitis.PloS one · 2010Article
- Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature.BMC research notes · 2010Article
- Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis.Journal of periodontology · 2009Article
- Aggressive periodontitis is likely influenced by a few small effect genes.Journal of clinical periodontology · 2009Article
- Evaluation of peripheral neutrophil functions in aggressive periodontitis patients and their family members in Indian population: An assessment of neutrophil chemotaxis, phagocytosis, and microbicidal activity.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Localized aggressive periodontitis (LAP; previously known as localized juvenile periodontitis) is one of the rapidly progressive periodontal diseases. Certain forms of familial LAP show a simple Mendelian pattern of transmission. However, no gene mutation has been identified to be responsible for the LAP phenotype. As an initial step to identify a gene mutation associated with LAP, we have performed genetic linkage analysis with four multigenerational families exhibiting the LAP phenotype. Affected individuals in the families were identified based on clinical and laboratory criteria in an attempt to define a homogeneous phenotype, since the clinical presentation of LAP may represent a manifestation of a heterogeneous group of diseases. The LAP phenotype is linked to a DNA marker, D1S492, with LOD score 3.48, theta=0.00. The haplotype analysis of the chromosome interval associated with D1S492 indicates that a LAP locus is located between D1S196 and D1S533 on chromosome 1, covering about 26 million DNA basepairs. We have also examined the DNA sequence of prostaglandin-endoperoxide synthase 2 (PTGS2 or cyclooxygenase 2, COX2) since prostaglandin 2 (PGE2), the product of COX2, is upregulated in LAP patients and COX2 is located between D1S196 and D1S533. No mutation in COX2 was identified in the patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.