ArticleMolecular and cellular biology2004
Assessment of splice variant-specific functions of desmocollin 1 in the skin.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Desmosomal Cadherins in Health and Disease.Annual review of pathology · 2022Review
- Identification of Docetaxel as a Potential Drug to Promote HDL Biogenesis.Frontiers in pharmacology · 2021Article
- Integrated, multicohort analysis reveals unified signature of systemic lupus erythematosus.JCI insight · 2020Article
- The Evolving Story of Autoantibodies in Pemphigus Vulgaris: Development of the "Super Compensation Hypothesis".Frontiers in medicine · 2018Review
- Lower DSC1 expression is related to the poor differentiation and prognosis of head and neck squamous cell carcinoma (HNSCC).Journal of cancer research and clinical oncology · 2016Article
- Plakoglobin as a regulator of desmocollin gene expression.The Journal of investigative dermatology · 2013Article
- Loss of Desmocollin 3 in skin tumor development and progression.Molecular carcinogenesis · 2012Article
- Cancer biomarker discovery: the entropic hallmark.PloS one · 2010Article
- No evidence of skin blisters with human desmocollin-3 gene mutation.American journal of human genetics · 2010Article
- Desmosomes at a glance.Journal of cell science · 2009Article
- Genetically engineered mouse models for skin research: taking the next step.Journal of dermatological science · 2008Review
- Loss of desmocollin 3 in mice leads to epidermal blistering.Journal of cell science · 2008Article
- Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation.Molecular and cellular biology · 2005Article
- Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice.Genes & development · 2004Article
- Desmosomes: just cell adhesion or is there more?Cell adhesion & migrationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Desmocollin 1 (Dsc1) is part of a desmosomal cell adhesion receptor formed in terminally differentiating keratinocytes of stratified epithelia. The dsc1 gene encodes two proteins (Dsc1a and Dsc1b) that differ only with respect to their COOH-terminal cytoplasmic amino acid sequences. On the basis of in vitro experiments, it is thought that the Dsc1a variant is essential for assembly of the desmosomal plaque, a structure that connects desmosomes to the intermediate filament cytoskeleton of epithelial cells. We have generated mice that synthesize a truncated Dsc1 receptor that lacks both the Dsc1a- and Dsc1b-specific COOH-terminal domains. This mutant transmembrane receptor, which does not bind the common desmosomal plaque proteins plakoglobin and plakophilin 1, is integrated into functional desmosomes. Interestingly, our mutant mice did not show the epidermal fragility previously observed in dsc1-null mice. This suggests that neither the Dsc1a- nor the Dsc1b-specific COOH-terminal cytoplasmic domain is required for establishing and maintaining desmosomal adhesion. However, a comparison of our mutants with dsc1-null mice suggests that the Dsc1 extracellular domain is necessary to maintain structural integrity of the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.