ArticleMolecular and cellular biology2004
Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The Spt10 GNAT Superfamily Protein Modulates Development, Cell Cycle Progression and Virulence in the Fungal Insect Pathogen,Journal of fungi (Basel, Switzerland) · 2021Article
- Boolean gene regulatory network model of centromere function in Saccharomyces cerevisiae.Journal of biological physics · 2019Article
- Regulation of DNA replication-coupled histone gene expression.Oncotarget · 2017Review
- Characterisation of functional domains in fission yeast Ams2 that are required for core histone gene transcription.Scientific reports · 2016Article
- Functions for diverse metabolic activities in heterochromatin.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration.Molecular and cellular biology · 2016Article
- Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Regulation of histone gene transcription in yeast.Cellular and molecular life sciences : CMLS · 2014Review
- Cell-cycle perturbations suppress the slow-growth defect of spt10Δ mutants in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2013Article
- H2B Tyr37 phosphorylation suppresses expression of replication-dependent core histone genes.Nature structural & molecular biology · 2012Article
- Regulation of histone gene expression in budding yeast.Genetics · 2012Review
- Spt10 and Swi4 control the timing of histone H2A/H2B gene activation in budding yeast.Molecular and cellular biology · 2011Article
- Intergenic transcription causes repression by directing nucleosome assembly.Genes & development · 2011Article
- Spt10 and Spt21 are required for transcriptional silencing in Saccharomyces cerevisiae.Eukaryotic cell · 2011Article
- Article
- The T body, a new cytoplasmic RNA granule in Saccharomyces cerevisiae.Molecular and cellular biology · 2008Article
- Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae.Molecular and cellular biology · 2007Article
- Identification of Rkr1, a nuclear RING domain protein with functional connections to chromatin modification in Saccharomyces cerevisiae.Molecular and cellular biology · 2007Article
- Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes.Molecular cell · 2007Article
- Cooperative binding of the yeast Spt10p activator to the histone upstream activating sequences is mediated through an N-terminal dimerization domain.Nucleic acids research · 2007Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Histone levels are a key factor in several nuclear processes, including transcription and chromosome segregation. Previous studies have demonstrated that Spt10 and Spt21 are required for the normal transcription of a subset of the histone genes in Saccharomyces cerevisiae, and sequence analysis has suggested that Spt10 is an acetyltransferase. We have now characterized several aspects of transcriptional activation of histone genes by Spt10 in vivo. Our results show that activation by Spt10 is dependent on its acetyltransferase domain. At HTA2-HTB2, the histone locus whose transcription is most strongly dependent on Spt10, Spt10 is physically recruited to the promoter in an Spt21-dependent and a cell cycle-dependent manner. Furthermore, Spt10 and Spt21 directly interact. These results, taken together with the identification of spt10 mutations that suppress an spt21Delta mutation, suggest a model for transcriptional activation by Spt10 and Spt21.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.