ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- A systematic review of animal models used to study nerve regeneration in tissue-engineered scaffolds.Biomaterials · 2012Pooled it
- Neural regeneration in the human central nervous system-from understanding the underlying mechanisms to developing treatments. Where do we stand today?Frontiers in neurology · 2024Review
- Translational bioengineering strategies for peripheral nerve regeneration: opportunities, challenges, and novel concepts.Neural regeneration research · 2023Review
- Long-Duration and Non-Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Thy-1 (CD90), Integrins and Syndecan 4 are Key Regulators of Skin Wound Healing.Frontiers in cell and developmental biology · 2022Review
- Effect of herbal extracts on peripheral nerve regeneration after microsurgery of the sciatic nerve in rats.BMC complementary medicine and therapies · 2021Article
- Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury.Biomaterials · 2021Article
- High resolution three-dimensional imaging of the ocular surface and intact eyeball using tissue clearing and light sheet microscopy.The ocular surface · 2020Article
- Adult Mouse Retina Explants: FromFrontiers in molecular neuroscience · 2020Article
- DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury.Neurobiology of disease · 2019Article
- Targeting Axon Integrity to Prevent Chemotherapy-Induced Peripheral Neuropathy.Molecular neurobiology · 2019Article
- Tubulation repair mitigates misdirection of regenerating motor axons across a sciatic nerve gap in rats.Scientific reports · 2018Article
- Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Methodological advances in imaging intravital axonal transport.F1000Research · 2017Review
- Epigenetic Regulation of Axon Regeneration after Neural Injury.Molecules and cells · 2017Review
- The Fluorescent Intensity from the Transgenic Thy1-Yellow Fluorescent Protein 16 Mouse Correlates with the Amount of Regenerated Axons.Plastic and reconstructive surgery. Global open · 2016Article
- Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.Neuron · 2015Article
- An in vitro assay to study induction of the regenerative state in sensory neurons.Experimental neurology · 2015Article
- Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line.PloS one · 2015Article
- Besides neuro-imaging, the Thy1-YFP mouse could serve for visualizing experimental tumours, inflammation and wound-healing.Scientific reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A direct histological assay of axonal regeneration would have many advantages over currently available behavioral, electrophysiological, and radiometric assays. We show that peripheral sensory axons marked with the yellow fluorescent protein in transgenic mice can be viewed transcutaneously in superficial nerves. Degenerating and regenerating axons can be followed in live animals with a dissecting microscope and then, after fixation, studied at high resolution by confocal microscopy. Using this approach, we document differences in regenerative ability after nerve transection, crush injury, and crush injury after a previous "conditioning" lesion. We also show that the chemotherapeutic drug vincristine rapidly but transiently blocks regeneration and that the immunosuppressive drug FK506 modestly enhances regeneration. Moreover, FK506 nearly restores normal regenerative ability in animals treated with submaximal doses of vincristine. Because neuropathy is the major dose-limiting side effect of vincristine, we propose that its efficacy could be enhanced by coadministration of FK506 analogs that are neuroactive but not immunosuppressive.
Indexed as
Identifiers
14673013PMC6740511W1960585860What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.