ArticleGenome research2004
Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
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- Alternatively spliced isoforms reveal a novel type of PTB domain in CCM2 protein.Scientific reports · 2019Article
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- MAP1B and NOS1 genes are associated with working memory in youths with attention-deficit/hyperactivity disorder.European archives of psychiatry and clinical neuroscience · 2016Article
- Where does transcription start? 5'-RACE adapted to next-generation sequencing.Nucleic acids research · 2016Article
- Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training.PloS one · 2016Article
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- Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9.Journal of molecular cell biology · 2015Article
- Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1).The Journal of biological chemistry · 2013Article
- Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve.Histochemistry and cell biology · 2013Review
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Identification of CTCF as a master regulator of the clustered protocadherin genes.Nucleic acids research · 2012Article
- UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
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- Genetic variations and haplotype diversity of the UGT1 gene cluster in the Chinese population.PloS one · 2012Article
- Before It Gets Started: Regulating Translation at the 5' UTR.Comparative and functional genomics · 2012Article
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3 authors.
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Abstract
A large family of neural protocadherin (Pcdh) proteins is encoded by three closely linked mammalian gene clusters (alpha, beta, and gamma). Pcdh alpha and gamma clusters have a striking genomic organization. Specifically, each "variable" exon is spliced to a common set of downstream "constant" exons within each cluster. Recent studies demonstrated that the cell-specific expression of each Pcdh gene is determined bya combination of variable-exon promoter activation and cis-splicing of the corresponding variable exon to the first constant exon. To determine whether there are other similarly organized gene clusters in mammalian genomes, we performed a genome-wide search and identified a large number of mammalian genes containing multiple variable first exons. Here we describe several clusters that contain about a dozen variable exons arrayed in tandem, including UDP glucuronosyltransferase (UGT1), plectin, neuronal nitric oxide synthase (NOS1), and glucocorticoid receptor (GR) genes. In all these cases, multiple variable first exons are each spliced to a common set of downstream constant exons to generate diverse functional mRNAs. As an example, we analyzed the tissue-specific expression profile of the mouse UGT1 repertoire and found that multiple isoforms are expressed in a tissue-specific manner. Therefore, this variable and constant genomic organization provides a genetic mechanism for directing distinct cell- and tissue-specific patterns of gene expression.
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