ArticleBMC genomics2003
The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function.
Article in BMC genomics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
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158 citing papers in PubMed, 350 citations in OpenAlex.
- High-variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum.The New phytologist · 2026Article
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- Genome-wide characterization of WD40 repeat proteins in cucumber reveals their functional roles in stress response and parthenocarpy.Scientific reports · 2025Article
- Insights into WDR5: unveiling its functions, regulation, and impact on skeletal muscle.Epigenetics · 2025Review
- Two WD40 proteins, AhWD40-170 and AhWD40-171, referred to regulation of anthocyanin accumulation in peanut (Arachis hypogaea L.).BMC plant biology · 2025Article
- AtGADD45A forms a complex with the scaffold protein AtRACK1A in response to DNA damage.Plant cell reports · 2025Article
- A transcriptional roadmap of the yearly growth cycle in Populus trees.The Plant cell · 2025Article
- Genome-wide identification and characterization of DCL, AGO and RDR gene families in sister mangrove speciesBiochemistry and biophysics reports · 2025Article
- Article
- Pan-WD40ome analysis of 26 diverse inbred lines reveals the structural and functional diversity of WD40 proteins in maize.BMC genomics · 2025Article
- Metabolomics and Transcriptomics Jointly Explore the Mechanism of Pod Color Variation in Purple Pod Pea.Current issues in molecular biology · 2025Article
- Interaction of PsMYB4 with PsEGL3 inhibits anthocyanin biosynthesis in tree peony yellow flowers.Frontiers in plant science · 2025Article
- Yield and yield component trait analysis with DArT genotyping for GWAS in soybean grown in drought conditions of Kazakhstan.Frontiers in plant science · 2025Article
- Perception and processing of stress signals by plant mitochondria.The Plant journal : for cell and molecular biology · 2024Review
- De Novo Transcriptome Assembly of Rice Bean (Plants (Basel, Switzerland) · 2024Article
- Transcriptome-wide Identification of Nine Tandem Repeat Protein Families in Roselle (Tropical life sciences research · 2024Article
- Article
- Pleiotropic regulatory locus 1 maintains actin cytoskeleton integrity and cellular homeostasis to enable Arabidopsis root growth.iScience · 2024Article
- Mapping the Influence of Light Intensity on the Transgenerational Genetic Architecture ofCurrent issues in molecular biology · 2024Article
98 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe WD motif (also known as the Trp-Asp or WD40 motif) is found in a multitude of eukaryotic proteins involved in a variety of cellular processes. Where studied, repeated WD motifs act as a site for protein-protein interaction, and proteins containing WD repeats (WDRs) are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In the model plant Arabidopsis thaliana, members of this superfamily are increasingly being recognized as key regulators of plant-specific developmental events.
resultsWe analyzed the predicted complement of WDR proteins from Arabidopsis, and compared this to those from budding yeast, fruit fly and human to illustrate both conservation and divergence in structure and function. This analysis identified 237 potential Arabidopsis proteins containing four or more recognizable copies of the motif. These were classified into 143 distinct families, 49 of which contained more than one Arabidopsis member. Approximately 113 of these families or individual proteins showed clear homology with WDR proteins from the other eukaryotes analyzed. Where conservation was found, it often extended across all of these organisms, suggesting that many of these proteins are linked to basic cellular mechanisms. The functional characterization of conserved WDR proteins in Arabidopsis reveals that these proteins help adapt basic mechanisms for plant-specific processes.
conclusionsOur results show that most Arabidopsis WDR proteins are strongly conserved across eukaryotes, including those that have been found to play key roles in plant-specific processes, with diversity in function conferred at least in part by divergence in upstream signaling pathways, downstream regulatory targets and /or structure outside of the WDR regions.
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