Evidence map›Paper›PMID 14672538›Full record

ReviewMolecular cancer2003

Role of APC and DNA mismatch repair genes in the development of colorectal cancers.

Satya Narayan, Deodutta Roy

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 192 citations in OpenAlex.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Satya NarayanDepartment of Anatomy and Cell Biology and UF Shands Cancer Center, College of Medicine, Academic Research Building, Room R4-216, 1600 SW Archer Road, University of Florida, Gainesville, FL 32610, USA. snarayan@ufscc.ufl.edu
Deodutta Roy
University of Alabama at Birmingham · USUniversity of Florida Health · US

Funding

Tumor suppressor APC and breast carcinogenesis.R01CA100247 · NCI · UNIVERSITY OF FLORIDA · PI NARAYAN, SATYA · 2003 to 2007
$1.4M
Involvement of APC in DNA RepairR01CA097031 · NCI · UNIVERSITY OF FLORIDA · PI NARAYAN, SATYA · 2003 to 2006
$1.0M
NCI NIH HHS CA-097031NCI NIH HHS CA-100247NCI NIH HHS R01 CA097031NCI NIH HHS R01 CA100247
6 · The paper itself

Abstract

Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S. in 2003, accounting for about 10% of cancer deaths. Among the colon cancer patients, hereditary risk contributes approximately 20%. The main inherited colorectal cancers are the familial adenomatous polyposis (FAP) and the hereditary nonpolyposis colorectal cancers (HNPCC). The FAP and HNPCC are caused due to mutations in the adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes. The focus of this review is to summarize the functions of APC and MMR gene products in the development of colorectal cancers.

Indexed as

Base Pair MismatchAdenomatous Polyposis Coli ProteinColorectal NeoplasmsDisease ProgressionDNA RepairHumansAdenomatous Polyposis Coli Protein

Identifiers

PMID14672538
PMCPMC317355
OpenAlexW2151463502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.