ArticleJournal of virology2004
Cultured peripheral neuroglial cells are highly permissive to sheep prion infection.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 85 citations in OpenAlex.
- Potential of Marine Sponge Metabolites against Prions: Bromotyrosine Derivatives, a Family of Interest.Marine drugs · 2024Article
- Genetically engineered cellular models of prion propagation.Cell and tissue research · 2023Review
- Propagation and Dissemination Strategies of Transmissible Spongiform Encephalopathy Agents in Mammalian Cells.International journal of molecular sciences · 2022Review
- Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- From Cell Culture to Organoids-Model Systems for Investigating Prion Strain Characteristics.Biomolecules · 2021Review
- Direct neural transmission of vCJD/BSE in macaque after finger incision.Acta neuropathologica · 2021Article
- An astrocyte cell line that differentially propagates murine prions.The Journal of biological chemistry · 2020Article
- Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line.Life science alliance · 2020Article
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- Efficient inhibition of infectious prions multiplication and release by targeting the exosomal pathway.Cellular and molecular life sciences : CMLS · 2015Article
- Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases.Acta neuropathologica communications · 2015Article
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- Prion propagation and toxicity occur in vitro with two-phase kinetics specific to strain and neuronal type.Journal of virology · 2013Article
- Cellular aspects of prion replication in vitro.Viruses · 2013Review
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- Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.The Journal of biological chemistry · 2010Article
- Infection of cell lines with experimental and natural ovine scrapie agents.Journal of virology · 2010Article
- Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmissible spongiform encephalopathies arise as a consequence of infection of the central nervous system (CNS) by prions. Spreading of the infectious agent through the peripheral nervous system (PNS) may represent a crucial step toward CNS neuroinvasion, but the modalities of this process have yet to be clarified. Here we provide further evidence that PNS glial cells are likely targets for infection by prions. Glial cell clones originating from dorsal root ganglia of transgenic mice expressing ovine PrP (tgOv) and simian virus 40 T antigen were found to be readily infectible by sheep scrapie agent. This led us to establish two stable cell lines that exhibited features of Schwann cells. These cells were shown to sustain an efficient and stable replication of sheep prion based on the high level of accumulation of abnormal PrP and infectivity in exposed cultures. We also provide evidence for abnormal PrP deposition in peripheral neuroglial cells from scrapie-infected tgOv mice and sheep. These findings have potential implications in terms of designing new cell systems permissive to prions and of peripheral pathobiology of prion infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.