ArticleJournal of endocrinological investigation2003
Prolactin effect on pre-pubertal Sertoli cell proliferation and metabolism.
Article in Journal of endocrinological investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Kidney disease and reproductive health.Nature reviews. Nephrology · 2025Review
- Comprehensive review on the positive and negative effects of various important regulators on male spermatogenesis and fertility.Frontiers in nutrition · 2022Review
- The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation.Frontiers in endocrinology · 2021Review
- Haploid Germ Cells Generated in Organotypic Culture of Testicular Tissue From Prepubertal Boys.Frontiers in physiology · 2018Article
- Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Hormonal control of inhibin B in men.Journal of endocrinological investigation · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct effects of PRL on Sertoli cell proliferation were investigated by using Sertoli cell primary cultures isolated from both prepubertal rat and porcine testes. PRL metabolic effects were analyzed in rat Sertoli cell primary cultures. Exposure to physiological doses of PRL resulted in a significant increase (+50-60%) of basal DNA synthesis, as reflected by the pattern of [3H] thymidine incorporation during culture; significant increases in lactate secretion (about 50%), androgen binding protein (ABP) production (about 30%) and basal protein synthesis (25-30%), as reflected in the augmented [14C] valine incorporation, were also evident. Taken together, our present findings, indicating significant effects of PRL on Sertoli cell proliferation and metabolism, demonstrate that Sertoli cells are a potential target for PRL action at testicular level during pre-pubertal development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.