Trial reportJournal of endocrinological investigation2003
Serum paraoxonase 1 activity is decreased in thyroid dysfunction.
Trial report in Journal of endocrinological investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- Another pleiotropic effect of SGLT2 inhibitors: Is it a new frontier in thyroid function regulation?Thyroid research · 2026Review
- Changes in biomarkers of the redox status in whole blood and red blood cell lysates in canine hypothyroidism.Veterinary research communications · 2024Article
- Hypothyroid women have persistently higher oxidative stress compared to healthy controls.European thyroid journal · 2023Article
- Changes in biomarkers of redox status in serum and saliva of dogs with hypothyroidism.BMC veterinary research · 2023Article
- The Role ofGlobal medical genetics · 2020Review
- Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates.Molecules (Basel, Switzerland) · 2020Article
- Thyroid Hormones in Conventional and Organic Farmers in Thailand.International journal of environmental research and public health · 2019Article
- Thyroid Hormones, Oxidative Stress, and Inflammation.Mediators of inflammation · 2016Review
- Thyroid nodules and thyroid autoimmunity in the context of environmental pollution.Reviews in endocrine & metabolic disorders · 2015Review
- Thyroid hormones and antioxidant systems: focus on oxidative stress in cardiovascular and pulmonary diseases.International journal of molecular sciences · 2013Review
- Paraoxonase enzyme activity and dyslipidemia in chronic kidney disease patients.Journal of nephropathology · 2012Article
- Novel associations of nonstructural Loci with paraoxonase activity.Journal of lipids · 2012Article
- Pleiotropic effects of thyroid hormones: learning from hypothyroidism.Journal of thyroid research · 2011Article
- Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case-control study.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in serum lipid and lipoprotein concentrations occur frequently in disorders of thyroid function. LDL-cholesterol (LDL-C) oxidation susceptibility is higher in these patients than in normal population. This study aims at assessing lipids, lipoproteins, apolipoproteins and serum paraoxonase 1 (PON1) activity in patients with thyroid dysfunction. Ninety-nine patients with thyroid dysfunction, (49 hypothyroid and 50 hyperthyroid) were compared with 2 separately age- and sex-matched control groups. A fasting blood sample was obtained and serum total cholesterol, triglycerides, apolipoproteins A-I and B, and PON1 activity were measured. In hyperthyroid patients, significantly lower PON1 activity (45 +/- 23 vs 67 +/- 37 IU/ml, p<0.001), triglycerides (112 +/- 53 vs 166 +/- 130 mg/dl, p<0.05), apolipoprotein A-I (137 +/- 26 vs 154 +/- 21 mg/dl, p<0.001) and apolipoprotein B (75 +/- 18 vs 86 +/- 25 mg/dl, p<0.05) were found. Hypothyroid patients had lower PON1 activity (46 +/- 21 vs 64 +/- 32 IU/ml, p<0.005) compared with controls, and higher total cholesterol (224 +/- 69 vs 185 +/- 41 mg/dl, p<0.001), LDL-C (133 +/- 59 vs 93 +/- 36 mg/dl, p<0.001), and apolipoprotein B (107 +/- 37 vs 84 +/- 23 mg/dl, p<0.001). The results show significant changes of lipid levels in thyroid dysfunction. In addition, a significant reduction in PON1 activity was observed in both hyper- and hypothyroid patients. Increased LDL-C oxidation in thyroid dysfunction observed in other studies, at least to some extent, can be attributed to reduced PON1 activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.