ArticleClinical & experimental metastasis2003
Biological properties and gene expression associated with metastatic potential of human osteosarcoma.
Article in Clinical & experimental metastasis, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 110 citations in OpenAlex.
- Review
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- Molecular Characterization of the Recombinant Ig1 Axl Receptor Domain: An Intriguing Bait for Screening in Drug Discovery.Molecules (Basel, Switzerland) · 2024Article
- Canine and murine models of osteosarcoma.Veterinary pathology · 2022Review
- The FAPActa pharmaceutica Sinica. B · 2022Article
- TAM kinase inhibition and immune checkpoint blockade- a winning combination in cancer treatment?Expert opinion on therapeutic targets · 2021Review
- Small Ones to Fight a Big Problem-Intervention of Cancer Metastasis by Small Molecules.Cancers · 2020Review
- Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer.The Journal of biological chemistry · 2020Article
- AXL Receptor Tyrosine Kinase as a Therapeutic Target in Hematological Malignancies: Focus on Multiple Myeloma.Cancers · 2019Review
- Rational Drug Design of Axl Tyrosine Kinase Type I Inhibitors as Promising Candidates Against Cancer.Frontiers in chemistry · 2019Article
- Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma.British journal of cancer · 2017Article
- WNT signaling - lung cancer is no exception.Respiratory research · 2017Review
- Blockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer.Scientific reports · 2017Article
- Tumourigenic canine osteosarcoma cell lines associated with frizzled-6 up-regulation and enhanced side population cell frequency.Veterinary and comparative oncology · 2017Article
- TAM receptor tyrosine kinase function and the immunopathology of liver disease.American journal of physiology. Gastrointestinal and liver physiology · 2016Review
- Osteosarcoma tissues and cell lines from patients with differing serum alkaline phosphatase concentrations display minimal differences in gene expression patterns.Veterinary and comparative oncology · 2016Article
- Article
- AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas.BMC cancer · 2015Article
- Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.Oncotarget · 2015Article
- Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lung metastasis has a great influence on the prognosis of patients with osteosarcoma. We previously established two high-metastatic sublines, M112 and M132, from the HuO9 human osteosarcoma cell line by in vivo selection. In this study, we newly isolated a high-metastatic subline, H3, and three low-metastatic sublines, L6, L12 and L13, from HuO9 by the dilution plating method. Three high-metastatic sublines produced more than 200 metastatic nodules in the lung, while three low-metastatic sublines produced no or few nodules after injection of 2 x 10(6) cells into the tail vein of nude mice. There were significant differences in the motility and invasiveness between high- and low-metastatic sublines, whereas the growth rates in vitro and the tumorigenicity in vivo showed no correlation with their metastatic abilities. Early adherence to culture plates was significantly lower in two of three low-metastatic sublines, which occupied smaller surface areas on the culture plates than other sublines did. Comparison of the expression of 637 cancer-related genes by cDNA microarray revealed that seven genes were differentially expressed between high- and low-metastatic sublines. Among them, five genes (AXL, TGFA, COLL7A1, WNT5A, and MKK6) were associated with adherence, motility, and/or invasiveness. These results suggest that the differences in motility/invasiveness and adhesive abilities are key determinants of lung metastasis in osteosarcoma.
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Registered trials
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