ArticleWorld journal of gastroenterology2003
Spider angiomas in patients with liver cirrhosis: role of vascular endothelial growth factor and basic fibroblast growth factor.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 65 citations in OpenAlex.
- Combined ultrasound and nerve stimulator-guided deep nerve block may decrease the rate of local anesthetics systemic toxicity: a randomized clinical trial.BMC anesthesiology · 2019Trial
- Multi-wavelength laser treatments of spider nevi.Lasers in medical science · 2019Trial
- Article
- Profile of serum levels of TNF-α, IL-1β, IL-6, IL-8, IL-12, adiponectin, and vitamin DClinical and experimental hepatology · 2025Article
- Experimental Liver Cirrhosis Inhibits Restenosis after Balloon Angioplasty.International journal of molecular sciences · 2023Article
- Article
- Spider Angioma Number and Location as Potential Prognostic Indicators in Chronic Liver Disease: A Case Report.Cureus · 2023Article
- Recognizing skin conditions in patients with cirrhosis: a narrative review.Annals of medicine · 2022Review
- A rare case of extensive cutaneous spider angioma in Zieve's syndrome: A case report and review of literature.Journal of family medicine and primary care · 2022Article
- A Simple and Quick Screening Method for Intrapulmonary Vascular Dilation in Cirrhotic Patients Based on Machine Learning.Journal of clinical and translational hepatology · 2021Article
- Spider Telangiectases and Palmar Erythema as Harbingers of Structural Liver Changes in Three Breast Cancer Patients on Ado-trastuzumab Emtansine.The Journal of clinical and aesthetic dermatology · 2019Article
- Impact of spider nevus and subcutaneous collateral vessel of chest/abdominal wall on outcomes of liver cirrhosis.Archives of medical science : AMS · 2019Article
- Effective treatment of gastrointestinal bleeding with thalidomide--Chances and limitations.World journal of gastroenterology · 2016Review
- Clinical and molecular characteristics of two transaldolase-deficient patients.European journal of pediatrics · 2014Article
- Circulating vascular endothelial growth factor and nitric oxide in patients with liver cirrhosis: A possible association with liver function impairment.Indian journal of clinical biochemistry : IJCB · 2009Article
- Angiogenic factor expression in hepatic cirrhosis.Mediators of inflammation · 2007Article
- The significance of cutaneous spider naevi in children.Archives of disease in childhood · 2006Article
- Bloody Lips - Gluing Bleeding Lower Lip Spider Angioma in Decompensated Cirrhosis.Journal of clinical and experimental hepatologyArticle
- A giant spider nevus in a patient of hepatitis C-related liver cirrhosis: A rare presentation.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) are associated with spider angiomas in patients with liver cirrhosis.
methodsEighty-six patients with liver cirrhosis were enrolled and the number and size of the spider angiomas were recorded. Fifty-three healthy subjects were selected as controls. Plasma levels of VEGF and bFGF were measured in both the cirrhotics and the controls.
resultsPlasma VEGF and bFGF were increased in cirrhotics compared with controls (122 +/- 13 vs. 71 +/- 11 pg/mL, P=0.003 for VEGF; 5.1 +/- 0.5 vs. 3.4 +/- 0.5 pg/mL, P=0.022 for bFGF). In cirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spider angiomas (185 +/- 28 vs. 90 +/- 10 pg/mL, P=0.003 for VEGF; 6.8 +/- 1.0 vs. 4.1 +/- 0.5 pg/mL, P=0.017 for bFGF). Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhotic patients (odds ratio [OR]=6.64, 95 % confidence interval [CI]=2.02-21.79, P=0.002; OR=4.35, 95% CI=1.35-14.01, P=0.014; OR=5.66, 95% CI=1.72-18.63, P=0.004, respectively).
conclusionPlasma VEGF and bFGF are elevated in patients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.
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