ArticleWorld journal of gastroenterology2003
Relationship between clinical and pathologic findings in patients with chronic liver diseases.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis.Aging and disease · 2024Review
- Impact of Breathing Phase, Liver Segment, and Prandial State on Ultrasound Shear Wave Speed, Shear Wave Dispersion, and Attenuation Imaging of the Liver in Healthy Volunteers.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Evaluation of the relation between hepatic fibrosis and basic laboratory parameters in patients with chronic hepatitis B fibrosis and basic laboratory parameters.Hepatitis monthly · 2014Article
- Extent of liver inflammation in predicting response to interferon α & Ribavirin in chronic hepatitis C patients: a cohort study.BMC gastroenterology · 2012Article
- Non-invasive markers for hepatic fibrosis.BMC gastroenterology · 2011Review
- Critical reappraisal of risk factors for occurrence of hepatocellular carcinoma in patients with hepatitis C virus.Hepatic medicine : evidence and research · 2011Review
- From bed to bench: which attitude towards the laboratory liver tests should health care practitioners strike?World journal of gastroenterology · 2007Review
- Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent.World journal of gastroenterology · 2006Article
- Diagnostic accuracy of serum biochemical fibrosis markers in children with chronic hepatitis B evaluated by receiver operating characteristics analysis.World journal of gastroenterology · 2005Article
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Authors and funding
16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the relationship between clinical findings of patients with chronic liver diseases and the pathologic grading and staging of liver tissues.
methodsThe inflammatory activity and fibrosis of consecutive liver biopsies from 200 patients were determined according to the diagnosis criteria of chronic hepatitis in China established in 1995. A comparative analysis was carried out for 200 patients with chronic liver diseases by comparing their clinical manifestations, serum biochemical markers with the grading and staging of liver tissues.
resultsIt was revealed that age, index of clinical symptoms and physical signs were obviously relevant to the pathologic grading and staging of liver tissues (P<0.05). Blood platelet, red blood cells, aspartate aminotransferase (AST), N-terminal procollagen III (PIII NP) were apparently correlated with the degree of inflammation. PGA (prothrombin time, GGT, apoprotein A1) index, PGAA (PGA+delta2-macroglobulin) index, albumin and albumin/globulin were relevant to both inflammation and fibrosis. Hyaluronic acid (HA) was an accurate variable for the severity of hepatic inflammation and fibrosis. The combination of serum markers for fibrosis could increase the diagnostic accuracy. It was notable that viral replication markers were not relevant to the degree of inflammation and fibrosis.
conclusionThere is a good correlation between clinical findings and the pathologic grading and staging of liver tissues, which may give aid to the noninvasive diagnosis of liver fibrosis.
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