ArticleWorld journal of gastroenterology2003
Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Research Progress on the Immunomodulatory Effects by Dang Gui (Molecules (Basel, Switzerland) · 2026Review
- Danggui Buxue Decoction Alleviates Inflammation and Oxidative Stress in Mice withVeterinary sciences · 2025Article
- A Potential Role of Plant/Macrofungi/Algae-Derived Non-Starch Polysaccharide in Colitis Curing: Review of Possible Mechanisms of Action.Molecules (Basel, Switzerland) · 2022Review
- Polysaccharides fromFrontiers in nutrition · 2022Article
- Herbal Medicine, Gut Microbiota, and COVID-19.Frontiers in pharmacology · 2021Review
- Synthesis, activity and mechanism of alkoxy-, carbamato-, sulfonamido-, thioureido-, and ureido-derivatives of 2,4,5-trimethylpyridin-3-ol against inflammatory bowel disease.Journal of enzyme inhibition and medicinal chemistry · 2020Article
- Advances in Research on Immunoregulation of Macrophages by Plant Polysaccharides.Frontiers in immunology · 2019Review
- Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure.Experimental and therapeutic medicine · 2018Article
- Purification, Preliminary Characterization and Hepatoprotective Effects of Polysaccharides from Dandelion Root.Molecules (Basel, Switzerland) · 2017Article
- Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis.Scientific reports · 2017Article
- Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis.Mediators of inflammation · 2016Article
- Antioxidant and physiological effects of Si-Wu-Tang on skin and liver: a randomized, double-blind, placebo-controlled clinical trial.Chinese medicine · 2016Article
- Differentiation of human adipose-derived stem cells into neuron-like cells by Radix Angelicae Sinensis.Neural regeneration research · 2013Article
- Protective effects of N-acetylcysteine on acetic acid-induced colitis in a porcine model.BMC gastroenterology · 2013Article
- Polysaccharides of St. John's Wort Herb Stimulate NHDF Proliferation and NEHK Differentiation via Influence on Extracellular Structures and Signal Pathways.Advances in pharmacological sciences · 2012Article
- Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction.Chinese medicine · 2011Article
- Keratinocyte growth factor gene therapy ameliorates ulcerative colitis in rats.World journal of gastroenterology · 2011Article
- The effect of Hypericum perforatum (St. John's Wort) on experimental colitis in rat.Digestive diseases and sciences · 2009Article
- Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats.Journal of ethnopharmacology · 2009Article
- The effects of caffeic acid phenethyl ester (CAPE) on TNBS-induced colitis in ovariectomized rats.Digestive diseases and sciences · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effect of angelica sinensis polysaccharide (ASP) on immunological colon injury and its mechanisms in rats.
methodsImmunological colitis model of rats was induced by intracolon enema with 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) and ethanol. The experimental animals were randomly divided into normal control, model control, 5-aminosalicylic acid therapy groups and three doses of ASP therapy groups. The 6 groups were treated intracolonically with normal saline, normal saline, 5-aminosalicylic acid (100 mg.kg(-1)), and ASP daily (8:00 am) at the doses of 200, 400 and 800 mg.kg(-1) respectively for 21 days 7 d following induction of colitis. The rat colon mucosa damage index (CMDI), the histopathological score (HS), the score of occult blood test (OBT), and the colonic MPO activity were evaluated. The levels of SOD, MDA, NO, TNF-alpha, IL-2 and IL-10 in colonic tissues were detected biochemically and immunoradiometrically. The expressions of TGF-beta and EGF in colonic tissues were also determined immunochemically.
resultsEnhanced colonic mucosal injury, inflammatory response and oxidative stress were observed in colitis rats, which manifested as significant increases of CMDI, HS, OBT, MPO activity, MDA and NO contents, as well as the levels of TNF-alpha and IL-2 in colonic tissues, although colonic TGF-beta protein expression, SOD activity and IL-10 content were significantly decreased compared with the normal control (P<0.01). However, these parameters were found to be significantly ameliorated in colitis rats treated intracolonically with ASP at the doses of 400 and 800 mg.kg(-1) (P<0.05-0.01). Meantime, colonic EGF protein expression in colitis rats was remarkably up-regulated.
conclusionASP has a protective effect on immunological colon injury induced by TNBS and ethanol enema in rats, which was probably due to the mechanism of antioxidation, immunomodulation and promotion of wound repair.
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