ArticleWorld journal of gastroenterology2003
Expression of Helicobacter pylori Hsp60 protein and its immunogenicity.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 31 citations in OpenAlex.
- Understanding GroEL and DnaK Stress Response Proteins as Antigens for Bacterial Diseases.Vaccines · 2020Review
- Review
- Mechanistic Insight Into the Interaction BetweenFrontiers in microbiology · 2019Article
- The Hsp60 protein of helicobacter pylori displays chaperone activity under acidic conditions.Biochemistry and biophysics reports · 2017Article
- In silico analysis to identify vaccine candidates common to multiple serotypes of Shigella and evaluation of their immunogenicity.PloS one · 2017Article
- H pylori and host interactions that influence pathogenesis.World journal of gastroenterology · 2006Review
- Fusion expression of Helicobacter pylori neutrophil-activating protein in E.coli.World journal of gastroenterology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo express Hsp60 protein of H pylori by a constructed vector and to evaluate its immunogenicity.
methodsHsp60 DNA was amplified by PCR and inserted into the prokaryote expression vector pET-22b (+), which was transformed into BL21 (DE3) E.coli strain to express recombinant protein. Immunogenicity of expressed Hsp60 protein was evaluated with animal experiments.
resultsDNA sequence analysis showed Hsp60 DNA was the same as GenBank's research. Hsp60 recombinant protein accounted for 27.2% of the total bacterial protein, and could be recognized by the serum from H pylori infected patients and Balb/c mice immunized with Hsp60 itself.
conclusionHsp60 recombinant protein might become a potential vaccine for controlling and treating H pylori infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.