ArticleOncogene2003
Chimaerism and erythroid marker expression after microinjection of human acute myeloid leukaemia cells into murine blastocysts.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Modulating DNA damage response in uveal melanoma through embryonic stem cell microenvironment.BMC cancer · 2024Article
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- Modifying the tumour microenvironment and reverting tumour cells: New strategies for treating malignant tumours.Cell proliferation · 2020Review
- Rescue effects: irradiated cells helped by unirradiated bystander cells.International journal of molecular sciences · 2015Review
- Article
- The relationship between early embryo development and tumourigenesis.Journal of cellular and molecular medicine · 2010Review
- Building a framework for embryonic microenvironments and cancer stem cells.Stem cell reviews and reports · 2009Review
- Phenotypic changes of human cells in human-rat liver during partial hepatectomy-induced regeneration.World journal of gastroenterology · 2009Article
- The magic behind stem cells.Journal of assisted reproduction and genetics · 2007Review
- Generation of human/rat xenograft animal model for the study of human donor stem cell behaviors in vivo.World journal of gastroenterology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that the embryonic microenvironment can control the survival and the transformed phenotype of tumour cells. Here, we addressed the hypothesis that the murine embryonic microenvironment can induce the differentiation of human tumour cells. To examine such interactions, we injected human leukaemic cells into preimplantation murine blastocysts at embryonic day 3.5 of gestation (E3.5). Microinjection of human KG-1 myeloid leukaemia cells and primary human acute myeloid leukaemia (AML) cells led to the generation of chimaeric embryos and adults. We observed that in E12.5 murine embryos, KG-1 cells were preferentially detected in yolk sac and peripheral blood, while primary AML cells mainly seeded the aorta gonad mesonephros region of chimaeric embryos. Analysis of the donor contribution in 15 different adult tissues showed that progeny of primary AML cells seeded to various haematopoietic and nonhaematopoietic tissues. Chimaeric embryos and adults showed no apparent tumour formation. Furthermore, analysis of chimaeric E12.5 embryos revealed that the progeny of human KG-1 cells activated erythroid-specific human globin and glycophorin A expression. In summary, our data indicate that human AML cells activate markers of erythroid differentiation after injection into early murine embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.