ArticleMolecular biology of the cell2004
gamma-tubulin plays an essential role in the coordination of mitotic events.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Emerging Roles of Tubulin Isoforms and Their Post-Translational Modifications in Microtubule-Based Transport and Cellular Functions.Biomolecules · 2026Review
- Review
- Location and functional analysis of the Aspergillus nidulans Aurora kinase confirm mitotic functions and suggest non-mitotic roles.Fungal genetics and biology : FG & B · 2017Article
- γ-Tubulin complexes in microtubule nucleation and beyond.Molecular biology of the cell · 2015Article
- Nup2 requires a highly divergent partner, NupA, to fulfill functions at nuclear pore complexes and the mitotic chromatin region.Molecular biology of the cell · 2015Article
- Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.Molecular microbiology · 2015Article
- Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleation.PloS one · 2013Article
- The GCP3-interacting proteins GIP1 and GIP2 are required for γ-tubulin complex protein localization, spindle integrity, and chromosomal stability.The Plant cell · 2012Article
- Feeding cells induced by phytoparasitic nematodes require γ-tubulin ring complex for microtubule reorganization.PLoS pathogens · 2011Article
- Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles.The EMBO journal · 2011Article
- Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase.The Journal of cell biology · 2010Article
- Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors.Development (Cambridge, England) · 2010Article
- The NDR kinase DBF-2 is involved in regulation of mitosis, conidial development, and glycogen metabolism in Neurospora crassa.Eukaryotic cell · 2010Article
- In vivo analysis of the functions of gamma-tubulin-complex proteins.Journal of cell science · 2009Article
- Nucleolar separation from chromosomes during Aspergillus nidulans mitosis can occur without spindle forces.Molecular biology of the cell · 2009Article
- Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans.Molecular biology of the cell · 2009Article
- gammaTub23C interacts genetically with brahma chromatin-remodeling complexes in Drosophila melanogaster.Genetics · 2008Article
- Article
- p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability.Oncogene · 2006Article
- Gamma-tubulin is essential for microtubule organization and development in Arabidopsis.The Plant cell · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Recent data from multiple organisms indicate that gamma-tubulin has essential, but incompletely defined, functions in addition to nucleating microtubule assembly. To investigate these functions, we examined the phenotype of mipAD159, a cold-sensitive allele of the gamma-tubulin gene of Aspergillus nidulans. Immunofluorescence microscopy of synchronized material revealed that at a restrictive temperature mipAD159 does not inhibit mitotic spindle formation. Anaphase A was inhibited in many nuclei, however, and after a slight delay in mitosis (approximately 6% of the cell cycle period), most nuclei reentered interphase without dividing. In vivo observations of chromosomes at a restrictive temperature revealed that mipAD159 caused a failure of the coordination of late mitotic events (anaphase A, anaphase B, and chromosomal disjunction) and nuclei reentered interphase quickly even though mitosis was not completed successfully. Time-lapse microscopy also revealed that transient mitotic spindle abnormalities, in particular bent spindles, were more prevalent in mipAD159 strains than in controls. In experiments in which microtubules were depolymerized with benomyl, mipAD159 nuclei exited mitosis significantly more quickly (as judged by chromosomal condensation) than nuclei in a control strain. These data reveal that gamma-tubulin has an essential role in the coordination of late mitotic events, and a microtubule-independent function in mitotic checkpoint control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.