ArticleMolecular biology of the cell2004
Global gene expression responses of fission yeast to ionizing radiation.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed.
- Transcriptom Analysis ofMycobiology · 2025Article
- Space exposure enhanced pectin-degrading enzymes expression and activity in Aspergillus costaricaensis.World journal of microbiology & biotechnology · 2023Article
- Maize ATR safeguards genome stability during kernel development to prevent early endosperm endocycle onset and cell death.The Plant cell · 2021Article
- Repression of a large number of genes requires interplay between homologous recombination and HIRA.Nucleic acids research · 2021Article
- XAP5 CIRCADIAN TIMEKEEPER Affects Both DNA Damage Responses and Immune Signaling inFrontiers in plant science · 2021Article
- Proteomics Reveals Distinct Changes Associated with Increased Gamma Radiation Resistance in the Black YeastGenes · 2020Article
- Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.Cell reports · 2017Article
- Microbial radiation-resistance mechanisms.Journal of microbiology (Seoul, Korea) · 2017Review
- Article
- Costs, benefits and redundant mechanisms of adaption to chronic low-dose stress in yeast.Cell cycle (Georgetown, Tex.) · 2016Article
- The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.Nucleic acids research · 2016Article
- Mechanotransduction as an Adaptation to Gravity.Frontiers in pediatrics · 2016Review
- Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated.Journal of cell science · 2013Article
- Regulation of transcriptome, translation, and proteome in response to environmental stress in fission yeast.Genome biology · 2012Article
- Adaptation of the black yeast Wangiella dermatitidis to ionizing radiation: molecular and cellular mechanisms.PloS one · 2012Article
- Break-induced ATR and Ddb1-Cul4(Cdt)² ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast.Genes & development · 2010Article
- The HOG pathway dictates the short-term translational response after hyperosmotic shock.Molecular biology of the cell · 2010Article
- Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms.Genes & development · 2010Article
- Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks.Cell cycle (Georgetown, Tex.) · 2010Review
- Global transcriptional response after exposure of fission yeast cells to ultraviolet light.BMC cell biology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A coordinated transcriptional response to DNA-damaging agents is required to maintain genome stability. We have examined the global gene expression responses of the fission yeast Schizosaccharomyces pombe to ionizing radiation (IR) by using DNA microarrays. We identified approximately 200 genes whose transcript levels were significantly altered at least twofold in response to 500 Gy of gamma IR in a temporally defined manner. The majority of induced genes were core environmental stress response genes, whereas the remaining genes define a transcriptional response to DNA damage in fission yeast. Surprisingly, few DNA repair and checkpoint genes were transcriptionally modulated in response to IR. We define a role for the stress-activated mitogen-activated protein kinase Sty1/Spc1 and the DNA damage checkpoint kinase Rad3 in regulating core environmental stress response genes and IR-specific response genes, both independently and in concert. These findings suggest a complex network of regulatory pathways coordinate gene expression responses to IR in eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.