ArticleGenetics2003
Detecting population growth, selection and inherited fertility from haplotypic data in humans.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- The Evolution of Genetic Variability at theGenes · 2024Article
- Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland.Human mutation · 2017Article
- The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution.Journal of the American Society of Nephrology : JASN · 2016Article
- Genetic and biochemical study of dual hereditary jaundice: Dubin-Johnson and Gilbert's syndromes. Haplotyping and founder effect of deletion in ABCC2.European journal of human genetics : EJHG · 2016Article
- Genesis of two most prevalent PROP1 gene variants causing combined pituitary hormone deficiency in 21 populations.European journal of human genetics : EJHG · 2016Article
- Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.European journal of human genetics : EJHG · 2013Article
- Founder effect and estimation of the age of the French Gypsy mutation associated with Glanzmann thrombasthenia in Manouche families.European journal of human genetics : EJHG · 2011Article
- Evolutionary genetics as a tool to target genes involved in phenotypes of medical relevance.Evolutionary applications · 2009Article
- Oculocutaneous albinism type 2 (OCA2) with homozygous 2.7-kb deletion of the P gene and sickle cell disease in a Cameroonian family. Identification of a common TAG haplotype in the mutated P gene.Journal of human genetics · 2007Article
- Matrilineal fertility inheritance detected in hunter-gatherer populations using the imbalance of gene genealogies.PLoS genetics · 2006Article
- Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.American journal of human genetics · 2006Article
- Contribution of a common single-nucleotide polymorphism to the genetic predisposition for erythropoietic protoporphyria.American journal of human genetics · 2006Article
- Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec.Human genetics · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequency of a rare mutant allele and the level of allelic association between this allele and one or several closely linked markers are frequently measured in genetic epidemiology. Both quantities are related to the time elapsed since the appearance of the mutation in the population and the intrinsic growth rate of the mutation (which may be different from the average population growth rate). Here, we develop a method that uses these two kinds of genetic data to perform a joint estimation of the age of the mutation and the minimum growth rate that is compatible with its present frequency. In absence of demographic data, it provides a useful estimate of population growth rate. When such data are available, contrasts among estimates from several loci allow demographic processes, affecting all loci similarly, to be distinguished from selection, affecting loci differently. Testing these estimates on populations for which data are available for several disorders shows good congruence with demographic data in some cases whereas in others higher growth rates are obtained, which may be the result of selection or hidden demographic processes.
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