ArticleGenetics2003
Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Polycomb-mediated transgenerational epigenetic inheritance ofOpen biology · 2025Article
- Identification and gene expression analysis of serine proteases and their homologs in the Asian corn borer Ostrinia furnacalis.Scientific reports · 2023Article
- Insights into the Temporal Gene Expression Pattern in Lymantria dispar Larvae During the Baculovirus Induced Hyperactive Stage.Virologica Sinica · 2018Article
- Genome-wide identification and expression profiling of serine proteases and homologs in the diamondback moth, Plutella xylostella (L.).BMC genomics · 2015Article
- Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes.G3 (Bethesda, Md.) · 2013Article
- Article
- Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis.Molecular biology of the cell · 2010Article
- Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.Development (Cambridge, England) · 2010Article
- A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila.PloS one · 2009Article
- Article
- Cell rearrangement and cell division during the tissue level morphogenesis of evaginating Drosophila imaginal discs.Developmental biology · 2008Article
- A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.Genetics · 2007Article
- The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila.Genetics · 2007Article
- Comparative analysis of serine protease-related genes in the honey bee genome: possible involvement in embryonic development and innate immunity.Insect molecular biology · 2006Article
- Mutational analysis of Stubble-stubbloid gene structure and function in Drosophila leg and bristle morphogenesis.Genetics · 2006Article
- Phenotypic analysis of mice lacking the Tmprss2-encoded protease.Molecular and cellular biology · 2006Article
- Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development.Developmental biology · 2005Article
- Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis.Genetics · 2003Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The Drosophila RhoA (Rho1) GTPase is essential for postembryonic morphogenesis of leg and wing imaginal discs. Mutations in RhoA enhance leg and wing defects associated with mutations in zipper, the gene encoding the heavy chain of nonmuscle myosin II. We demonstrate here that mutations affecting the RhoA signaling pathway also interact genetically with mutations in the Stubble-stubbloid (Sb-sbd) locus that encodes an unusual type II transmembrane serine protease required for normal leg and wing morphogenesis. In addition, a leg malformation phenotype associated with overexpression of Sb-sbd in prepupal leg discs is suppressed when RhoA gene dose is reduced, suggesting that RhoA and Sb-sbd act in a common pathway during leg morphogenesis. We also characterized six mutations identified as enhancers of zipper mutant leg defects. Three of these genes encode known members of the RhoA signaling pathway (RhoA, DRhoGEF2, and zipper). The remaining three enhancer of zipper mutations interact genetically with both RhoA and Sb-sbd mutations, suggesting that they encode additional components of the RhoA signaling pathway in imaginal discs. Our results provide evidence that the type II transmembrane serine proteases, a class of proteins linked to human developmental abnormalities and pathology, may be associated with intracellular signaling required for normal development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.