ArticleGenetics2003
Linkage disequilibrium patterns across a recombination gradient in African Drosophila melanogaster.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- Elevated Linkage Disequilibrium and Signatures of Soft Sweeps Are Common in Drosophila melanogaster.Genetics · 2016Article
- Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster.Molecular ecology · 2016Article
- Massive habitat-specific genomic response in D. melanogaster populations during experimental evolution in hot and cold environments.Molecular biology and evolution · 2014Article
- The effect of variable frequency of sexual reproduction on the genetic structure of natural populations of a cyclical parthenogen.Evolution; international journal of organic evolution · 2012Article
- Article
- Population-based resequencing of experimentally evolved populations reveals the genetic basis of body size variation in Drosophila melanogaster.PLoS genetics · 2011Article
- Effects of inversions on within- and between-species recombination and divergence.Genome biology and evolution · 2011Article
- Estimating parameters of speciation models based on refined summaries of the joint site-frequency spectrum.PloS one · 2011Article
- The rate of fitness-valley crossing in sexual populations.Genetics · 2010Article
- Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis.Journal of molecular evolution · 2010Article
- Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- High DNA sequence diversity in pericentromeric genes of the plant Arabidopsis lyrata.Genetics · 2008Article
- Article
- Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Hitchhiking effects of recurrent beneficial amino acid substitutions in the Drosophila melanogaster genome.Genome research · 2007Article
- A new approach to estimate parameters of speciation models with application to apes.Genome research · 2007Article
- Chromosome-wide linkage disequilibrium as a consequence of meiotic drive.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- Estimating recombination rates from single-nucleotide polymorphisms using summary statistics.Genetics · 2006Article
- Widespread discordance of gene trees with species tree in Drosophila: evidence for incomplete lineage sorting.PLoS genetics · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous multilocus surveys of nucleotide polymorphism have documented a genome-wide excess of intralocus linkage disequilibrium (LD) in Drosophila melanogaster and D. simulans relative to expectations based on estimated mutation and recombination rates and observed levels of diversity. These studies examined patterns of variation from predominantly non-African populations that are thought to have recently expanded their ranges from central Africa. Here, we analyze polymorphism data from a Zimbabwean population of D. melanogaster, which is likely to be closer to the standard population model assumptions of a large population with constant size. Unlike previous studies, we find that levels of LD are roughly compatible with expectations based on estimated rates of crossing over. Further, a detailed examination of genes in different recombination environments suggests that markers near the telomere of the X chromosome show considerably less linkage disequilibrium than predicted by rates of crossing over, suggesting appreciable levels of exchange due to gene conversion. Assuming that these populations are near mutation-drift equilibrium, our results are most consistent with a model that posits heterogeneity in levels of exchange due to gene conversion across the X chromosome, with gene conversion being a minor determinant of LD levels in regions of high crossing over. Alternatively, if levels of exchange due to gene conversion are not negligible in regions of high crossing over, our results suggest a marked departure from mutation-drift equilibrium (i.e., toward an excess of LD) in this Zimbabwean population. Our results also have implications for the dynamics of weakly selected mutations in regions of reduced crossing over.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.