ArticleGenetics2003
Effect of the Suppressor of Underreplication (SuUR) gene on position-effect variegation silencing in Drosophila melanogaster.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.eLife · 2016Article
- The effects of SUUR protein suggest its role in repressive chromatin renewal during replication in Drosophila.Nucleus (Austin, Tex.) · 2015Article
- Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cells.Genes & development · 2014Article
- Developmental variation of the SUUR protein binding correlates with gene regulation and specific chromatin types in D. melanogaster.Chromosoma · 2014Article
- Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner.Chromosoma · 2013Article
- Genome-wide profiling of forum domains in Drosophila melanogaster.Nucleic acids research · 2011Article
- The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Article
- Review
- Local DNA underreplication correlates with accumulation of phosphorylated H2Av in the Drosophila melanogaster polytene chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Article
- Replication of heterochromatin: insights into mechanisms of epigenetic inheritance.Chromosoma · 2005Review
- System for purification of complexes of the Drosophila melanogaster chromosomal protein SUUR.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been previously shown that the SuUR gene encodes a protein located in intercalary and pericentromeric heterochromatin in Drosophila melanogaster polytene chromosomes. The SuUR mutation suppresses the formation of ectopic contacts and DNA underreplication in polytene chromosomes; SuUR+ in extra doses enhances the expression of these characters. This study demonstrates that heterochromatin-dependent PEV silencing is also influenced by SuUR. The SuUR protein localizes to chromosome regions compacted as a result of PEV; the SuUR mutation suppresses DNA underreplication arising in regions of polytene chromosomes undergoing PEV. The SuUR mutation also suppresses variegation of both adult morphological characters and chromatin compaction observed in rearranged chromosomes. In contrast, SuUR+ in extra doses and its overexpression enhance variegation. Thus, SuUR affects PEV silencing in a dose-dependent manner. However, its effect is expressed weaker than that of the strong modifier Su(var)2-5.
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