ArticleGenetics2003
Heterochromatic self-association, a determinant of nuclear organization, does not require sequence homology in Drosophila.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of Chromatin Structure Modifiers on the trans-Acting Heterochromatin Position Effect in Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2023Article
- Chromatin Structure and "DNA Sequence View": The Role of Satellite DNA in Ectopic Pairing of theInternational journal of molecular sciences · 2021Article
- Article
- Article
- Three-dimensional architecture of tandem repeats in chicken interphase nucleus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.PLoS genetics · 2014Article
- Article
- A genome-wide screen identifies genes that affect somatic homolog pairing in Drosophila.G3 (Bethesda, Md.) · 2012Article
- How can satellite DNA divergence cause reproductive isolation? Let us count the chromosomal ways.Genetics research international · 2012Article
- Ninety years of Drosophila melanogaster hybrids.Genetics · 2010Article
- Review
- Article
- Interplay of developmentally regulated gene expression and heterochromatic silencing in trans in Drosophila.Genetics · 2008Article
- Article
- Cell-by-cell dissection of gene expression and chromosomal interactions reveals consequences of nuclear reorganization.PLoS biology · 2005Article
- Sequence elements in cis influence heterochromatic silencing in trans.Molecular and cellular biology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomes of higher eukaryotes contain blocks of heterochromatin that can associate with each other in the interphase nucleus. A well-studied example of heterochromatic interaction is the brown(Dominant) (bwD) chromosome of D. melanogaster, which contains an approximately 1.6-Mbp insertion of AAGAG repeats near the distal tip of chromosome 2. This insertion causes association of the tip with the centric heterochromatin of chromosome 2 (2h), which contains megabases of AAGAG repeats. Here we describe an example, other than bwD, in which distally translocated heterochromatin associates with centric heterochromatin. Additionally, we show that when a translocation places bwD on a different chromosome, bwD tends to associate with the centric heterochromatin of this chromosome, even when the chromosome contains a small fraction of the sequence homology present elsewhere. To further test the importance of sequence homology in these interactions, we used interspecific mating to introgress the bwD allele from D. melanogaster into D. simulans, which lacks the AAGAG on the autosomes. We find that D. simulans bwD associates with 2h, which lacks the AAGAG sequence, while it does not associate with the AAGAG containing X chromosome heterochromatin. Our results show that intranuclear association of separate heterochromatic blocks does not require that they contain the same sequence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.