ArticleGenetics2003
Patterns of selection against transposons inferred from the distribution of Tc1, Tc3 and Tc5 insertions in the mut-7 line of the nematode Caenorhabditis elegans.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The role of transposon activity in shapingGenome research · 2025Article
- Bioinformatics and Machine Learning Approaches to Understand the Regulation of Mobile Genetic Elements.Biology · 2021Review
- Degradation of the Repetitive Genomic Landscape in a Close Relative of Caenorhabditis elegans.Molecular biology and evolution · 2020Article
- Coevolution between transposable elements and recombination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Natural Variation in the Distribution and Abundance of Transposable Elements Across the Caenorhabditis elegans Species.Molecular biology and evolution · 2017Article
- Evolution of a transposon in Daphnia hybrid genomes.Mobile DNA · 2013Article
- Population genomics of transposable elements in Drosophila melanogaster.Molecular biology and evolution · 2011Article
- Genome-wide analysis of Tol2 transposon reintegration in zebrafish.BMC genomics · 2009Article
- Epigenetic silencing of transposable elements: a trade-off between reduced transposition and deleterious effects on neighboring gene expression.Genome research · 2009Article
- The evolutionary dynamics of the Helena retrotransposon revealed by sequenced Drosophila genomes.BMC evolutionary biology · 2009Article
- DNA transposons and the evolution of eukaryotic genomes.Annual review of genetics · 2007Review
- Transposable element orientation bias in the Drosophila melanogaster genome.Journal of molecular evolution · 2005Article
- High-resolution genome-wide mapping of transposon integration in mammals.Molecular and cellular biology · 2005Article
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6 authors.
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Abstract
To identify the factors (selective or mutational) that affect the distribution of transposable elements (TEs) within a genome, it is necessary to compare the pattern of newly arising element insertions to the pattern of element insertions that have been fixed in a population. To do this, we analyzed the distribution of recent mutant insertions of the Tc1, Tc3, and Tc5 elements in a mut-7 background of the nematode Caenorhabditis elegans and compared it to the distribution of element insertions (presumably fixed) within the sequenced genome. Tc1 elements preferentially insert in regions with high recombination rates, whereas Tc3 and Tc5 do not. Although Tc1 and Tc3 both insert in TA dinucleotides, there is no clear relationship between the frequency of insertions and the TA dinucleotide density. There is a strong selection against TE insertions within coding regions: the probability that a TE will be fixed is at least 31 times lower in coding regions than in noncoding regions. Contrary to the prediction of theoretical models, we found that the selective pressure against TE insertions does not increase with the recombination rate. These findings indicate that the distribution of these three transposon families in the genome of C. elegans is determined essentially by just two factors: the pattern of insertions, which is a characteristic of each family, and the selection against insertions within coding regions.
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