ArticleGenetics2003
The SONB(NUP98) nucleoporin interacts with the NIMA kinase in Aspergillus nidulans.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- In Mitosis You Are Not: The NIMA Family of Kinases inInternational journal of molecular sciences · 2022Review
- The Quest for the Blueprint of the Nuclear Pore Complex.The protein journal · 2019Review
- Uncleavable Nup98-Nup96 is functional in the fission yeast Schizosaccharomyces pombe.FEBS open bio · 2015Article
- Restraint of the G2/M transition by the SR/RRM family mRNA shuttling binding protein SNXAHRB1 in Aspergillus nidulans.Genetics · 2014Article
- The Set1/COMPASS histone H3 methyltransferase helps regulate mitosis with the CDK1 and NIMA mitotic kinases in Aspergillus nidulans.Genetics · 2014Article
- "Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinases.World journal of biological chemistry · 2014Review
- Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA.Eukaryotic cell · 2014Article
- Identification of interphase functions for the NIMA kinase involving microtubules and the ESCRT pathway.PLoS genetics · 2014Article
- Article
- The NIMA kinase is required to execute stage-specific mitotic functions after initiation of mitosis.Eukaryotic cell · 2014Article
- Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies.Molecular biology of the cell · 2013Article
- Nuclear dynamics, mitosis, and the cytoskeleton during the early stages of colony initiation in Neurospora crassa.Eukaryotic cell · 2010Article
- Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.Oncogene · 2010Article
- Double duty for nuclear proteins--the price of more open forms of mitosis.Trends in genetics : TIG · 2009Review
- Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor.Molecular & cellular proteomics : MCP · 2009Article
- The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.Molecular and cellular biology · 2009Article
- Copy number suppressors of the Aspergillus nidulans nimA1 mitotic kinase display distinctive and highly dynamic cell cycle-regulated locations.Eukaryotic cell · 2008Article
- Mitosis, not just open or closed.Eukaryotic cell · 2007Review
- Mitotic regulation by NIMA-related kinases.Cell division · 2007Article
- An in vitro nuclear disassembly system reveals a role for the RanGTPase system and microtubule-dependent steps in nuclear envelope breakdown.The Journal of cell biology · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Aspergillus nidulans NIMA kinase is essential for mitotic entry. At restrictive temperature, temperature-sensitive nimA alleles arrest in G2, before accumulation of NIMA in the nucleus. We performed a screen for extragenic suppressors of the nimA1 allele and isolated two cold-sensitive son (suppressor of nimA1) mutants. The sonA1 mutant encoded a nucleoporin that is a homolog of yeast Gle2/Rae1. We have now cloned SONB, a second nucleoporin genetically interacting with NIMA. sonB is essential and encodes a homolog of the human NUP98/NUP96 precursor. Similar to NUP98/NUP96, SONB(NUP98/NUP96) is autoproteolytically cleaved to generate SONB(NUP98) and SONB(NUP96). SONB(NUP98) localizes to the nuclear pore complex and contains a GLEBS domain (Gle2 binding sequence) that binds SONA(GLE2). A point mutation within the GLEBS domain of SONB1(NUP98) suppresses the temperature sensitivity of the nimA1 allele and compromises the physical interaction between SONA(GLE2) and SONB1(NUP98). The sonB1 mutation also causes sensitivity to hydroxyurea. We isolated the histone H2A-H2B gene pair as a copy-number suppressor of sonB1 cold sensitivity and hydroxyurea sensitivity. The data suggest that the nucleoporins SONA(GLE2) and SONB(NUP98) and the NIMA kinase interact and regulate nuclear accumulation of mitotic regulators to help promote mitosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.