ArticleGenetics2003
Evolution in Saccharomyces cerevisiae: identification of mutations increasing fitness in laboratory populations.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Template switching during DNA replication is a prevalent source of adaptive gene amplification.eLife · 2025Article
- Template switching during DNA replication is a prevalent source of adaptive gene amplification.bioRxiv : the preprint server for biology · 2024Article
- Segregating Complete Tf2 Elements Are Largely Neutral in Fission Yeast.Genome biology and evolution · 2021Article
- The functional basis of adaptive evolution in chemostats.FEMS microbiology reviews · 2015Review
- Adaptation of Drosophila melanogaster to increased NaCl concentration due to dominant beneficial mutations.Genetica · 2011Article
- Rapid increase in viability due to new beneficial mutations in Drosophila melanogaster.Genetica · 2010Article
- The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast.PLoS genetics · 2008Article
- Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae.Nature genetics · 2008Article
- Comparing whole genomes using DNA microarrays.Nature reviews. Genetics · 2008Review
- Global mapping of transposon location.PLoS genetics · 2006Article
- High-resolution mutation mapping reveals parallel experimental evolution in yeast.PLoS biology · 2006Article
- Loss of dispensable genes is not adaptive in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The uses of genome-wide yeast mutant collections.Genome biology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Since the publication of the complete sequence of the genome of Saccharomyces cerevisiae, a number of comprehensive investigations have been initiated to gain insight into cellular function. The focus of these studies has been to identify genes essential for survival in specific environments or those that when mutated cause gross phenotypic defects in growth. Here we describe Ty1-based mutational approaches designed to identify genes, which when mutated generate evolutionarily significant phenotypes causing small but positive increments on fitness. As expected, Ty1 mutations with a positive fitness effect were in the minority. However, mutations in two loci, one inactivating FAR3 and one upstream of CYR1, identified in evolving populations, were shown to have small but significantly positive fitness effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.