ArticleThe British journal of nutrition2003
Mitochondrial energy metabolism in a model of undernutrition induced by dexamethasone.
Article in The British journal of nutrition, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment.International journal of molecular sciences · 2022Article
- Reduced PGC-1β protein expression may underlie corticosterone inhibition of mitochondrial biogenesis and oxidative phosphorylation in chicken muscles.Frontiers in physiology · 2022Article
- Article
- Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.Journal of proteomics · 2017Article
- Article
- Effects of exercise and metformin on the prevention of glucose intolerance: a comparative study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Amelioration of an undesired action of deguelin.Toxicon : official journal of the International Society on Toxinology · 2013Article
- A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure.American journal of physiology. Endocrinology and metabolism · 2012Article
- Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats.The Journal of trauma · 2009Article
- The metabolic changes caused by dexamethasone in the adjuvant-induced arthritic rat.Molecular and cellular biochemistry · 2007Article
- Dexamethasone impairs muscle energetics, studied by (31)P NMR, in rats.Diabetologia · 2005Article
- Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment.The Biochemical journal · 2004Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present investigation was undertaken to evaluate whether mitochondrial energy metabolism is altered in a model of malnutrition induced by dexamethasone (DEX) treatment (1.5 mg/kg per d for 5 d). The gastrocnemius and liver mitochondria were isolated from DEX-treated, pair-fed (PF) and control (CON) rats. Body weight was reduced significantly more in the DEX-treated group (-16%) than in the PF group (-9%). DEX treatment increased liver mass (+59% v. PF, +23% v. CON) and decreased gastrocnemius mass. Moreover, in DEX-treated rats, liver mitochondria had an increased rate of non-phosphorylative O2 consumption with all substrates (approximately +42%). There was no difference in enzymatic complex activities in liver mitochondria between rat groups. Collectively, these results suggest an increased proton leak and/or redox slipping in the liver mitochondria of DEX-treated rats. In addition, DEX decreased the thermodynamic coupling and efficiency of oxidative phosphorylation. We therefore suggest that this increase in the proton leak and/or redox slip in the liver is responsible for the decrease in the thermodynamic efficiency of energy conversion. In contrast, none of the variables of energy metabolism determined in gastrocnemius mitochondria was altered by DEX treatment. Therefore, it appears that DEX specifically affects mitochondrial energy metabolism in the liver.
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