ArticleJournal of neurophysiology2003
Availability of low-threshold Ca2+ current in retinal ganglion cells.
Article in Journal of neurophysiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics.eLife · 2020Article
- Synchrony of Spontaneous Burst Firing between Retinal Ganglion Cells Across Species.Experimental neurobiology · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Article
- CaV3.2 KO mice have altered retinal waves but normal direction selectivity.Visual neuroscience · 2015Article
- The effect of morphology upon electrophysiological responses of retinal ganglion cells: simulation results.Journal of computational neuroscience · 2014Article
- Intrinsic physiological properties of the five types of mouse ganglion-cell photoreceptors.Journal of neurophysiology · 2013Article
- Expression of CaV3.2 T-type Ca²⁺ channels in a subpopulation of retinal type-3 cone bipolar cells.Neuroscience · 2012Article
- Modelling intrinsic electrophysiological properties of ON and OFF retinal ganglion cells.Journal of computational neuroscience · 2011Article
- Calcium currents of olfactory bulb juxtaglomerular cells: profile and multiple conductance plateau potential simulation.Neuroscience · 2011Article
- Electrical synaptic input to ganglion cells underlies differences in the output and absolute sensitivity of parallel retinal circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Hypertension induced by angiotensin II and a high salt diet involves reduced SK current and increased excitability of RVLM projecting PVN neurons.Journal of neurophysiology · 2010Article
- Dendritic calcium signaling in ON and OFF mouse retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Mechanisms and distribution of ion channels in retinal ganglion cells: using temperature as an independent variable.Journal of neurophysiology · 2010Article
- Functional stability of retinal ganglion cells after degeneration-induced changes in synaptic input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Article
- Different mechanisms generate maintained activity in ON and OFF retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Ih without Kir in adult rat retinal ganglion cells.Journal of neurophysiology · 2007Article
- Transmission of spike trains at the retinogeniculate synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Olfactoretinal centrifugal input modulates zebrafish retinal ganglion cell activity: a possible role for dopamine-mediated Ca2+ signalling pathways.The Journal of physiology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Spiking in central neurons depends on the availability of inward and outward currents activated by depolarization and on the activation and priming of currents by hyperpolarization. Of these processes, priming by hyperpolarization is the least described. In the case of T-type Ca2+ current availability, the interplay of hyperpolarization and depolarization has been studied most completely in expression systems, in part because of the difficulty of pharmacologically separating the Ca2+ currents of native neurons. To facilitate understanding of this current under physiological conditions, we measured T-type current of isolated goldfish retinal ganglion cells with perforated-patch voltage-clamp methods in solutions containing a normal extracellular Ca2+ concentration. The voltage sensitivities and rates of current activation, inactivation, deactivation, and recovery from inactivation were similar to those of expressed alpha1G (CaV3.1) Ca2+ channel clones, except that the rate of deactivation was significantly faster. We reproduced the amplitude and kinetics of measured T currents with a numerical simulation based on a kinetic model developed for an alpha1G Ca2+ channel. Finally, we show that this model predicts the increase of T-type current made available between resting potential and spike threshold by repetitive hyperpolarizations presented at rates that are within the bandwidth of signals processed in situ by these neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.