ArticleGenes & development2003
Senseless acts as a binary switch during sensory organ precursor selection.
Article in Genes & development, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi.Genetics · 2023Article
- Genetic and Molecular Interactions betweenGenes · 2023Article
- Single-cell Senseless protein analysis reveals metastable states during the transition to a sensory organ fate.iScience · 2022Article
- GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.Scientific reports · 2022Article
- Sex-specific evolution of a Drosophila sensory system via interacting cis- and trans-regulatory changes.Evolution & development · 2022Article
- Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate.PLoS genetics · 2022Article
- Repurposing the lineage-determining transcription factor Atoh1 without redistributing its genomic binding sites.Frontiers in cell and developmental biology · 2022Article
- Arf6 is necessary for senseless expression in response to wingless signalling during Drosophila wing development.Biology open · 2021Article
- smiFISH and embryo segmentation for single-cell multi-gene RNA quantification in arthropods.Communications biology · 2021Article
- Single-cell visualization of mir-9a and Senseless co-expression during Drosophila melanogaster embryonic and larval peripheral nervous system development.G3 (Bethesda, Md.) · 2021Article
- Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence.Development (Cambridge, England) · 2020Article
- Ordered patterning of the sensory system is susceptible to stochastic features of gene expression.eLife · 2020Article
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- Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized.PLoS genetics · 2018Article
- UsingDisease models & mechanisms · 2018Review
- Patterning mechanisms diversify neuroepithelial domains in the Drosophila optic placode.PLoS genetics · 2018Article
- Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.Advances in experimental medicine and biology · 2018Review
- Developmental Plasticity and Robustness of a Nematode Mouth-Form Polyphenism.Frontiers in genetics · 2018Review
- Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor, plays an important role in this process. We show that Sens is directly activated by proneural proteins in the presumptive SOPs and a few cells surrounding the SOP in most tissues. In the cells that express low levels of Sens, it acts in a DNA-binding-dependent manner to repress transcription of proneural genes. In the presumptive SOPs that express high levels of Sens, it acts as a transcriptional activator and synergizes with proneural proteins. We therefore propose that Sens acts as a binary switch that is fundamental to SOP selection.
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