ArticleEukaryotic cell2003
pH response transcription factor PacC controls salt stress tolerance and expression of the P-Type Na+ -ATPase Ena1 in Fusarium oxysporum.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- The Vacuolar CaMolecular plant pathology · 2026Article
- Unveiling the Role of StuA in Transcription Regulation in Trichophyton rubrum: From Global Regulation Dynamics to the pH-Responsive Program Control.Mycopathologia · 2025Article
- Harboring Starships: The Accumulation of Large Horizontal Gene Transfers in Domesticated and Pathogenic Fungi.Genome biology and evolution · 2025Article
- Transcription factors SltA and CrzA reversely regulate calcium homeostasis under calcium-limited conditions.Applied and environmental microbiology · 2023Article
- VmPacC-mediated pH regulation of Valsa mali confers to host acidification identified by comparative proteomics analysis.Stress biology · 2023Article
- Role of the Global Fitness Regulator Genes on the Osmotic Tolerance Ability and Salinity Hazard Alleviation ofJournal of fungi (Basel, Switzerland) · 2022Article
- P-type NaVirulence · 2020Article
- Saline stress affects the pH-dependent regulation of the transcription factor PacC in the dermatophyte Trichophyton interdigitale.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Screening of Fungi for Potential Application of Self-Healing Concrete.Scientific reports · 2019Article
- The pH Signaling Transcription Factor PAC-3 Regulates Metabolic and Developmental Processes in Pathogenic Fungi.Frontiers in microbiology · 2019Article
- VmPacC Is Required for Acidification and Virulence inFrontiers in microbiology · 2018Article
- Live-cell imaging of conidial anastomosis tube fusion during colony initiation in Fusarium oxysporum.PloS one · 2018Article
- Membrane lipids and soluble sugars dynamics of the alkaliphilic fungus Sodiomyces tronii in response to ambient pH.Extremophiles : life under extreme conditions · 2017Article
- Carbon regulation of environmental pH by secreted small molecules that modulate pathogenicity in phytopathogenic fungi.Molecular plant pathology · 2016Article
- Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories.Current genomics · 2016Article
- How Does Host Carbon Concentration Modulate the Lifestyle of Postharvest Pathogens during Colonization?Frontiers in plant science · 2016Review
- Fungal model systems and the elucidation of pathogenicity determinants.Fungal genetics and biology : FG & B · 2014Review
- Are alkalitolerant fungi of the Emericellopsis lineage (Bionectriaceae) of marine origin?IMA fungus · 2013Article
- PacC and pH-dependent transcriptome of the mycotrophic fungus Trichoderma virens.BMC genomics · 2013Article
- Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia.Applied and environmental microbiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungi possess efficient mechanisms of pH and ion homeostasis, allowing them to grow over a wide range of environmental conditions. In this study, we addressed the role of the pH response transcription factor PacC in salt tolerance of the vascular wilt pathogen Fusarium oxysporum. Loss-of-function pacC(+/-) mutants showed increased sensitivity to Li(+) and Na(+) and accumulated higher levels of these cations than the wild type. In contrast, strains expressing a dominant activating pacC(c) allele were more salt tolerant and had lower intracellular Li(+) and Na(+) concentrations. Although the kinetics of Li(+) influx were not altered by mutations in pacC, we found that Li(+) efflux at an alkaline, but not at an acidic, ambient pH was significantly reduced in pacC(+/-) loss-of-function mutants. To explore the presence of a PacC-dependent efflux mechanism in F. oxysporum, we cloned ena1 encoding an orthologue of the yeast P-type Na(+)-ATPase ENA1. Northern analysis revealed that efficient transcriptional activation of ena1 in F. oxysporum required the presence of high Na(+) concentrations and alkaline ambient pH and was dependent on PacC function. We propose a model in which PacC controls ion homeostasis in F. oxysporum at a high pH by activating expression of ena1 coordinately with a second Na(+)-responsive signaling pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.